{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:31:41Z","timestamp":1784759501897,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T00:00:00Z","timestamp":1349913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["320000-122089"],"award-info":[{"award-number":["320000-122089"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["310030-140736"],"award-info":[{"award-number":["310030-140736"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lucie and Ernst Schmidheiny foundation"},{"name":"Telemaque Foundation","award":["Gustave and Simone Prevot Foundation and the DeReuters foundation"],"award-info":[{"award-number":["Gustave and Simone Prevot Foundation and the DeReuters foundation"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Background and Objective<\/jats:title>Anti\u2010apolipoprotein A<\/jats:styled-content>\u20101 (anti\u2010apoA<\/jats:styled-content>\u20101) I<\/jats:styled-content>gG<\/jats:styled-content> is a potential marker of atherosclerotic plaque vulnerability and cardiovascular complications. In patients with periodontitis the presence of anti\u2010apoA<\/jats:styled-content>\u20101 IgGs in serum and their association with atherosclerosis is unknown.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>One\u2010hundred and thirty subjects with periodontal disease and 46 healthy subjects, matched for age and gender, participated in this study. Anti\u2010apoA<\/jats:styled-content>\u20101 I<\/jats:styled-content>gG<\/jats:styled-content>, high\u2010sensitivity C<\/jats:styled-content>\u2010reactive protein (hsCRP<\/jats:styled-content>) and matrix metalloproteinase (MMP<\/jats:styled-content>) \u20102, \u20103, \u20108 and \u20109 were measured in serum samples. An ankle\u2010brachial index (ABI<\/jats:styled-content>) value below 1.11 served as a surrogate marker of atherosclerosis. Predictive accuracies of biomarkers for abnormal ABI<\/jats:styled-content> were determined using receiver\u2013operating characteristics curves and logistic regression analyses.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with healthy controls, periodontitis patients showed lower median ABI<\/jats:styled-content> values (1.10 vs. 1.15; p<\/jats:italic>\u00a0<\u00a00.0001), a higher prevalence of anti\u2010apoA<\/jats:styled-content>\u20101 I<\/jats:styled-content>gG<\/jats:styled-content> positivity (23.8% vs. 6.5%; p<\/jats:italic>\u00a0=\u00a00.009) and higher concentrations of hsCRP<\/jats:styled-content> (1.62\u00a0mg\/L vs. 0.85\u00a0mg\/L; p<\/jats:italic>\u00a0=\u00a00.02) and MMP<\/jats:styled-content>\u20109 (435\u00a0\u03bcg\/mL vs. 283\u00a0\u03bcg\/mL; p<\/jats:italic>\u00a0<\u00a00.0001). In patients younger than 50\u00a0years of age (n<\/jats:italic>\u00a0=\u00a066), anti\u2010apoA<\/jats:styled-content>\u20101 I<\/jats:styled-content>gG<\/jats:styled-content> was found to be the best predictor for an abnormal ABI<\/jats:styled-content> (area under the curve = 0.63; p<\/jats:italic>\u00a0=\u00a00.03). Anti\u2010apoA<\/jats:styled-content>\u20101 I<\/jats:styled-content>gG<\/jats:styled-content> positivity increased the risk of having an abnormal ABI<\/jats:styled-content> (odds ratio = 4.20; p<\/jats:italic>\u00a0=\u00a00.04), independently of diabetes, smoking and body mass index.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Anti\u2010apoA<\/jats:styled-content>\u20101 I<\/jats:styled-content>gG<\/jats:styled-content> positivity and atherosclerosis, as reflected by abnormal ABI<\/jats:styled-content>, were more prevalent in periodontitis patients than in age\u2010 and gender\u2010matched controls. In younger periodontitis patients, anti\u2010apoA<\/jats:styled-content>\u20101 I<\/jats:styled-content>gG<\/jats:styled-content> was found to be the best predictor of atherosclerosis burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12014","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T14:26:43Z","timestamp":1349965603000},"page":"350-356","source":"Crossref","is-referenced-by-count":24,"title":["Anti\u2010apolipoprotein A<\/scp>\u20101 autoantibodies as biomarker for atherosclerosis burden in patients with periodontitis"],"prefix":"10.1111","volume":"48","author":[{"given":"P. A.","family":"Wick","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mombelli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pagano","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine, Department of Genetics and Laboratory Medicine Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Moren","sequence":"additional","affiliation":[{"name":"Service of Laboratory Medicine, Department of Genetics and Laboratory Medicine Geneva University Hospitals Geneva 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