{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:08:02Z","timestamp":1780445282436,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T00:00:00Z","timestamp":1358121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Romanian Ministry of Education and Research","award":["CNCSIS IDEI 1341\/2008"],"award-info":[{"award-number":["CNCSIS IDEI 1341\/2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate whether the combination of enamel matrix derivative (<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) with subepithelial connective tissue graft (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content>) plus coronally advanced flap (<jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>) would improve the treatment outcomes of Miller class I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> gingival recessions when compared with the same technique (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>) alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was designed as a randomized, parallel, controlled, double\u2010blinded clinical trial. Forty\u2010two patients were randomly assigned in the test group (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) and in the control group (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content>). Patients had at least one <jats:styled-content style=\"fixed-case\">gingival recession<\/jats:styled-content> \u2265\u00a02\u00a0mm. The clinical parameters were evaluated at baseline and at 14 d, 1, 3, 6 and 12 mo follow\u2010up time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients, 21 in the test group (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) and 21 in the control group (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content>), aged 21\u201348\u00a0years (mean age 31\u00a0\u00b1\u00a08.56) were initially included in the study. Both treatments, <jats:styled-content style=\"fixed-case\">STCG<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content>, resulted in a significant final mean root coverage (2.91\u00a0\u00b1\u00a00.95mm and 2.91\u00a0\u00b1\u00a01.29\u00a0mm, respectively) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and in a high mean percentage of root coverage (82.25\u00a0\u00b1\u00a022.20% and 89.75\u00a0\u00b1\u00a017.33%, respectively) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), 1\u00a0year after surgery. The differences in mean root coverage recorded for the two techniques after 1\u00a0year, were not statistically significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.19). Complete root coverage was achieved in 56.5% of patients treated with <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> and in 70.6% of patients treated with <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.275), 1\u00a0year after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study failed to demonstrate any additional clinical benefits when <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> was added to <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12039","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T14:20:46Z","timestamp":1358173246000},"page":"563-572","source":"Crossref","is-referenced-by-count":41,"title":["Subepithelial connective tissue graft with or without enamel matrix derivative for the treatment of <scp>M<\/scp>iller class <scp>I<\/scp> and <scp>II<\/scp> gingival recessions: a controlled randomized clinical trial"],"prefix":"10.1111","volume":"48","author":[{"given":"A.","family":"Roman","sequence":"first","affiliation":[{"name":"Department of Periodontology Iuliu Hatieganu University of Medicine and Pharmacy Str. 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