{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:09:54Z","timestamp":1790834994724,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","award":["FAPESP: 00\/09234-4"],"award-info":[{"award-number":["FAPESP: 00\/09234-4"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","award":["99\/08446-9"],"award-info":[{"award-number":["99\/08446-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Major depressive disorder (MDD) has been associated with alterations in the neuroendocrine system and immune function and may be associated with an increased susceptibility to cardiovascular disease, cancer and autoimmune\/inflammatory disease. This study was conducted to investigate the relationship between periodontitis and MDD in a convenience sample of hospital outpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The sample consisted of 72 physically healthy subjects (36 outpatients with MDD and 36 age\u2010matched controls [\u00b1\u00a03\u00a0years]). Patients with bipolar disorder, eating disorders and psychotic disorders were excluded. Probing pocket depth and clinical attachment level were recorded at six sites per tooth. Depression was assessed by means of Structured Clinical Interview for DSM\u2010IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Extent of clinical attachment level and probing pocket depth were not different between controls and subjects with depression for the following thresholds: \u2265\u00a03\u00a0mm (Mann\u2013Whitney, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.927 and 0.756); \u2265\u00a04\u00a0mm (Mann\u2013Whitney, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.656 and 0.373); \u2265\u00a05\u00a0mm (Mann\u2013Whitney, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.518 and 0.870);, and \u2265\u00a06\u00a0mm (Mann\u2013Whitney, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.994 and 0.879). Depression parameters were not associated with clinical attachment level \u2265\u00a05\u00a0mm in this sample. Smoking was associated with loss of attachment \u2265\u00a05\u00a0mm in the multivariable logistic regression model (odds ratio\u00a0=\u00a06.99, 95% confidence interval\u00a0=\u00a02.00\u201324.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this sample, periodontal clinical parameters were not different between patients with MDD and control subjects. There was no association between depression and periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12082","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T07:20:43Z","timestamp":1366096843000},"page":"77-84","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of periodontitis in hospital outpatients with major depressive disorder"],"prefix":"10.1111","volume":"49","author":[{"given":"A. C. O.","family":"Solis","sequence":"first","affiliation":[{"name":"Department of Stomatology Discipline of Periodontics School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Epidemiology New York Columbia University New York NY USA"},{"name":"Department and Institute of Psychiatry School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Pannuti","sequence":"additional","affiliation":[{"name":"Department of Stomatology Discipline of Periodontics School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F. 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