{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:41:48Z","timestamp":1776858108350,"version":"3.51.2"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T00:00:00Z","timestamp":1366761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Straumann Institut"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Epidemiologic and clinical studies have indicated that diabetes is a risk factor for periodontal disease progression and healing. The aim of the present study was to evaluate short\u2010term healing after enamel matrix derivative (<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) application in combined supra\/infrabony periodontal defects in diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Thirty male <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>istar rats were initially divided into two groups, one with streptozotocin\u2010induced diabetes and another one with healthy (non\u2010diabetic) animals. Bony defects were surgically created on the mesial root of the first maxillary molars. After root surface planing and <jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content> conditioning, <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> was applied to the roots at one side of the maxillae, while those on the contralateral sides were left untreated. Animals were killed 3\u00a0wk after surgery, and block sections were prepared for histologic and histomorphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was statistically significant more gingival recession in diabetic animals than in non\u2010diabetic animals. The length of the junctional epithelium was significantly shorter in the <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>\u2010treated sites in both diabetic and normoglycemic rats. Sulcus depth and length of supracrestal soft connective tissue showed no statistically significant differences between groups. In all animals, new bone formation was observed. Although new bone occurred more frequently in healthy animals, the extent of new bone was not significantly different between groups. In none of the teeth, a layer of new cementum was detectable. <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> had no influence on bone or cementum regeneration. Adverse reactions such as excessive inflammation due to bacterial root colonization, ankylosis and bone fractures were exclusively observed in diabetic animals, irrespective of <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limits of the present study, it can be concluded that periodontal healing was impaired in <jats:styled-content style=\"fixed-case\">streptozotocin<\/jats:styled-content>\u2010induced diabetic rats. <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> had no beneficial effects on new bone and cementum formation during short\u2010term healing in this defect model and could not ameliorate the adverse effects in the systemically compromised animals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12084","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T07:42:43Z","timestamp":1366789363000},"page":"93-101","source":"Crossref","is-referenced-by-count":29,"title":["Periodontal healing after application of enamel matrix derivative in surgical supra\/infrabony periodontal defects in rats with streptozotocin\u2010induced diabetes"],"prefix":"10.1111","volume":"49","author":[{"given":"Y.","family":"Shirakata","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Department of Periodontology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Eliezer","sequence":"additional","affiliation":[{"name":"Department of Periodontology The Maurice and Goldschleger School of Dental Medicine Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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