{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:40:22Z","timestamp":1791081622729,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation Emphases Item of China","doi-asserted-by":"crossref","award":["30973313"],"award-info":[{"award-number":["30973313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Glycosylated extracellular matrix metalloproteinase inducer (<jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content>) is specifically associated with <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101 and influences its ability to induce matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s) production. This study investigated <jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> glycosylation and <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101 expression in healthy and inflamed human gingival tissues, analyzed the relationship between <jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> glycosylation and <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101 expression, and assessed how this interaction influenced <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Gingival tissues were collected from 10 healthy subjects and 15 chronic periodontitis (<jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content>) subjects. <jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content>, caveolin\u20101 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 expressions were analyzed by immunohistochemistry. <jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101 co\u2010localization was detected by immunofluorescence. <jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> glycosylation, <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101, active <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 and pro<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 expression was assessed by Western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast\u2010like cells. Strong <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed <jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101 co\u2010localization in gingival epithelium, endothelial and fibroblast\u2010like cells. Compared with healthy subjects, the <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> group had increased high\u2010glycoform <jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content>) and active <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 expression (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). Active <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 and pro<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 protein levels were positively correlated with <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> levels (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>aveolin\u20101 colocalize in periodontal tissues. The increased active <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 and pro<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 production may be associated with elevated <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EMMPRIN<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12095","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T11:05:04Z","timestamp":1367924704000},"page":"197-204","source":"Crossref","is-referenced-by-count":26,"title":["Expression of <scp>extracellular matrix metalloproteinase inducer<\/scp> glycosylation and <scp>c<\/scp>aveolin\u20101 in healthy and inflamed human gingiva"],"prefix":"10.1111","volume":"49","author":[{"given":"J.","family":"Wang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Periodontology School and Hospital of Stomatology Wuhan University Wuhan 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