{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:25Z","timestamp":1787015665657,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Colgate-Palmolive Company, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>\n                      There is a paucity of data in relation to the possible emergence of triclosan (\n                      <jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content>\n                      )\u2010resistant bacteria following long\u2010term exposure to\n                      <jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content>\n                      toothpaste. Therefore, this study investigated whether long\u2010term continuous exposure to\n                      <jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content>\n                      in toothpaste selects for\n                      <jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content>\n                      \u2010resistant bacteria within the oral biofilm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Dental plaque samples were collected from 40 individuals during year 5 of a randomised controlled trial. Participants had been randomly assigned to use TCS (3000\u00a0\u03bcg\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      TCS) (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      18) or placebo toothpaste (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      22). Diluted plaque samples were plated on to Wilkins\u2013Chalgren agar plates containing 5% (v\/v) laked sheep red blood cells and TCS (concentrations ranging from 25 to 150\u00a0\u03bcg\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      ) and incubated at 37\u00b0C under microaerophilic and anaerobic conditions for 2\u201310\u00a0d. Selected bacterial isolates were identified by partial 16S\n                      <jats:styled-content style=\"fixed-case\">rDNA<\/jats:styled-content>\n                      sequencing and TCS minimum inhibitory concentration (MIC) determined for each isolate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3000\u00a0\u03bcg\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      TCS no growth was observed under microaerophilic or anaerobic conditions in either group. The MICs of TCS for all isolates ranged from 125 to 1000\u00a0\u03bcg\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      in both groups. Species common to both groups had similar MICs.\n                      <jats:italic>Veillonella parvula<\/jats:italic>\n                      and\n                      <jats:italic>Campylobacter gracilis<\/jats:italic>\n                      were the most frequent isolates from both groups, with similar MICs in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The use of\n                      <jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content>\n                      \u2010containing toothpaste did not appear to lead to an increase in\n                      <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>\n                      of\n                      <jats:styled-content style=\"fixed-case\">TCS<\/jats:styled-content>\n                      of oral bacterial isolates.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12098","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T06:01:24Z","timestamp":1368511284000},"page":"220-225","source":"Crossref","is-referenced-by-count":11,"title":["No evidence of triclosan\u2010resistant bacteria following long\u2010term use of triclosan\u2010containing toothpaste"],"prefix":"10.1111","volume":"49","author":[{"given":"M. P.","family":"Cullinan","sequence":"first","affiliation":[{"name":"Sir John Walsh Research Institute University of Otago Dunedin New Zealand"},{"name":"School of Medicine Prince Charles Hospital University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Bird","sequence":"additional","affiliation":[{"name":"School of Veterinary Science University of Queensland Gatton Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. C. K.","family":"Heng","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"West","sequence":"additional","affiliation":[{"name":"School of Medicine Prince Charles Hospital University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute University of Otago Dunedin New Zealand"},{"name":"School of Medicine Prince Charles Hospital University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh171"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0110"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.20030.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.02811.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2006.12.83"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00722.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1995.tb00150.x"},{"key":"e_1_2_6_9_1","first-page":"259","article-title":"Efficacy of a triclosan\/NaF dentifrice in the control of plaque and gingivitis and concurrent oral microflora monitoring","volume":"11","author":"Fine DH","year":"1998","journal-title":"Am J Dent"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01206.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00292.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00486.x"},{"key":"e_1_2_6_13_1","volume-title":"Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria","author":"National Committee for Clinical Laboratory Standards","year":"1997"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/28970"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.39.100185.001135"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00636.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/516237"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl023"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2004.02402.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibiod.2005.11.002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2005.01790.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.16.11110"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/18803"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3240"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2907"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01152-09"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.428-432.2001"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2003.11"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02757-09"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.11.3343-3347.2002"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.12098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:42:42Z","timestamp":1696192962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/jre.12098"],"URL":"https:\/\/doi.org\/10.1111\/jre.12098","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]}}}