{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:57:26Z","timestamp":1790474246284,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T00:00:00Z","timestamp":1369958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>There is a substantial magnitude of data implicating the role of interleukin\u201023 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023) in the initiation and progression of periodontal disease. The main aim of this study was to evaluate the levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 in the gingival crevicular fluid of systemically healthy subjects in periodontal health and disease. In addition, we explored the effectiveness of periodontal interventional therapy on the levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 in subjects with chronic periodontitis to obtain a deeper insight into the possible role of IL\u201023 in three separate periodontal conditions in three different populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this study, 54 individuals, satisfying the study inclusion and exclusion criteria, were recruited. They were categorically divided, on the basis of <jats:styled-content style=\"fixed-case\">g<\/jats:styled-content>ingival index, <jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>robing pocket depth and relative attachment loss, into three groups: <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 1 (patients with a clinically healthy periodontium, <jats:italic>n<\/jats:italic>\u00a0=\u00a018); <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 2 (patients with gingivitis, <jats:italic>n<\/jats:italic>\u00a0=\u00a018); and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 3a (patients with chronic periodontitis, <jats:italic>n<\/jats:italic>\u00a0=\u00a018). Samples taken from all 18 subjects of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 3a, 3\u00a0mo after the initial therapy, constituted <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 3b. All clinical parameters were recorded at baseline and 3\u00a0mo after scaling and root planing. Gingival crevicular fluid samples were obtained in which the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 concentration was measured using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The highest mean <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 concentration in gingival crevicular fluid was found for <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 3a (16448.69\u00a0pg\/mL) and the lowest for <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 1 (2565.28\u00a0pg\/mL). The mean <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 concentrations in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 2 (5425\u00a0pg\/mL) and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 3b (6272.22\u00a0pg\/mL) lay between the maximum and minimum values. This implies a positive correlation between the gingival crevicular fluid <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 concentration and relative attachment loss (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A noteworthy increase in the gingival crevicular fluid <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 concentration was seen that was proportional to the amount of periodontal tissue damage. As the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 concentration in gingival crevicular fluid is directly proportional to the severity of the periodontal affliction, it can be speculated that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 has a possible role in the pathogenesis of periodontal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12100","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T07:24:43Z","timestamp":1369985083000},"page":"237-245","source":"Crossref","is-referenced-by-count":26,"title":["Gingival crevicular fluid and interleukin\u201023 concentration in systemically healthy subjects: their relationship in periodontal health and disease"],"prefix":"10.1111","volume":"49","author":[{"given":"G. S.","family":"Himani","sequence":"first","affiliation":[{"name":"Department of Periodontics MGM Dental College and Hospital Navi Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L. V.","family":"Prabhuji","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology Krishnadevaraya College of Dental Sciences and Hospital Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. V.","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implantology Krishnadevaraya College of Dental Sciences and Hospital Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700908"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.12.6812"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6713.2004.003557.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03522.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02257.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509339889"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.10.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.04.027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100643"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00676.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060458"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00684.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70367-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01403.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1736"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.8.5625"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02361.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737635"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602326"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.51.261"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1973.tb00773.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01624.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.3.S67"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1976.tb00060.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838742"},{"key":"e_1_2_7_30_1","first-page":"75","article-title":"Serum levels of interleukin (IL)\u201013, IL\u201017 and IL\u201018 in patients with ischemic heart disease","volume":"9","author":"Jafarzadeh A","year":"2009","journal-title":"Anadolu Kardiyol Derg"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:42:48Z","timestamp":1696207368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,31]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/jre.12100"],"URL":"https:\/\/doi.org\/10.1111\/jre.12100","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,31]]}}}