{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:01:08Z","timestamp":1773396068488,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T00:00:00Z","timestamp":1376611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Foundation Project of Shanghai Health Bureau","award":["2009019"],"award-info":[{"award-number":["2009019"]}]},{"DOI":"10.13039\/501100001809","name":"national Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81001202"],"award-info":[{"award-number":["81001202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Background and Objective<\/jats:title>Systemic macrolide antibiotic administration has been shown to result in the elimination or reduction cyclosporine A<\/jats:styled-content>\u2010induced gingival overgrowth. R<\/jats:styled-content>oxithromycin (ROX<\/jats:styled-content>) is known to have anti\u2010inflammatory, immunomodulatory and tissue reparative effects. This study was to evaluate the effect of adjunctive ROX<\/jats:styled-content> therapy on cyclosporine A<\/jats:styled-content>\u2010induced gingival overgrowth<\/jats:styled-content> and interleukin (IL<\/jats:styled-content>)\u20101\u03b2, transforming growth factor (TGF<\/jats:styled-content>)\u2010\u03b21<\/jats:sub> and vascular endothelial growth factor (VEGF<\/jats:styled-content>) levels in gingival crevicular fluid of renal transplant patients.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Thirty\u2010one patients with clinically significant overgrowth and 16 periodontally healthy subjects were included in this randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010arm study. Patients received scaling and root planing (SRP<\/jats:styled-content>) at baseline and randomized to take either ROX<\/jats:styled-content> or placebo for 5\u00a0d. The clinical parameters, including plaque index, papillary bleeding index, probing depth and gingival overgrowth<\/jats:styled-content> scores, were recorded. The amounts of IL<\/jats:styled-content>\u20101\u03b2, TGF<\/jats:styled-content>\u2010\u03b21<\/jats:sub> and VEGF<\/jats:styled-content> in gingival crevicular fluid<\/jats:styled-content> were detected by ELISA<\/jats:styled-content>. Periodontal parameters as well as gingival crevicular fluid<\/jats:styled-content> biomarker levels were evaluated at baseline and at 1 and 4\u00a0wk post\u2010therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>Following SRP<\/jats:styled-content> plus ROX<\/jats:styled-content> and SRP<\/jats:styled-content> plus placebo therapy, significant improvements in clinical periodontal parameters of both study groups were observed (p\u00a0<\/jats:italic><\u00a00.025). In the ROX<\/jats:styled-content> group, adjunctive ROX<\/jats:styled-content> therapy resulted in a greater gingival overgrowth<\/jats:styled-content> scores reduction compared with those in the placebo group at 4\u00a0wk (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.017). Initial amounts of IL<\/jats:styled-content>\u20101\u03b2, TGF<\/jats:styled-content>\u2010\u03b21<\/jats:sub> and VEGF<\/jats:styled-content> for both the ROX<\/jats:styled-content> and placebo groups were significantly higher than those for healthy subjects (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.017), with no statistical difference between the two study groups. At 1 and 4\u00a0wk post\u2010therapy, significant decreases in the amounts of IL<\/jats:styled-content>\u20101\u03b2, TGF<\/jats:styled-content>\u2010\u03b21<\/jats:sub> and VEGF<\/jats:styled-content> were observed in both study groups when compared with baseline (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.025), but there was no difference in the levels of IL<\/jats:styled-content>\u20101\u03b2 and VEGF<\/jats:styled-content> between the two study groups. The amount of decrease in TGF<\/jats:styled-content>\u2010\u03b21<\/jats:sub> levels for the ROX<\/jats:styled-content> group was statistically significant compared to that for the placebo group at 4\u00a0wk after treatment (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.017).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study indicated that combination of ROX<\/jats:styled-content> with non\u2010surgical therapy improves gingival overgrowth<\/jats:styled-content> status and decreases gingival crevicular fluid TGF<\/jats:styled-content>\u2010\u03b21<\/jats:sub> levels in patients with severe gingival overgrowth<\/jats:styled-content>. The reduction of gingival crevicular fluid TGF<\/jats:styled-content>\u2010\u03b21<\/jats:sub> following ROX<\/jats:styled-content> therapy suggests an anti\u2010inflammatory\/immunomodulatory effect of ROX<\/jats:styled-content> on the treatment of cyclosporine A<\/jats:styled-content>\u2010induced gingival overgrowth<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12123","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T09:57:15Z","timestamp":1376647035000},"page":"448-457","source":"Crossref","is-referenced-by-count":14,"title":["Effect of adjunctive roxithromycin therapy on interleukin\u20101\u03b2, transforming growth factor\u2010\u03b21 and vascular endothelial growth factor in gingival crevicular fluid of cyclosporine A<\/scp>\u2010treated patients with gingival overgrowth"],"prefix":"10.1111","volume":"49","author":[{"given":"Y.","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Stomatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Ninth People's Hospital Shanghai Jiao Tong University, School of Medicine Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Stomatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01272.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004217.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500305"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00930.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.6.587"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11.1098"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809430"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00724.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00774.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199806270-00012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.12.2694"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701263580"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1397-3142.2003.00067.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.9.2039b"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00383.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01418.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808701110"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.380"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.04.012"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-8-17"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00695.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-9-33"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1546"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_26_1","first-page":"905","article-title":"Motivation and education","volume":"85","author":"Saxer UP","year":"1975","journal-title":"SSO Schweiz Monatsschr Zahnheilkd"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb01377.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00251.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2004.00521.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1535"},{"key":"e_1_2_7_31_1","first-page":"156","article-title":"Anti\u2010inflammatory activity of macrolide antibiotics","volume":"292","author":"Ianaro A","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1024"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35666-1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.6.808"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2003.09.002"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050086"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2267"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300505.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.11.1625"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.526"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.02895.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3520"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027010738.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.12.1464"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.7.784"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.02.010"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01338.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.2.181"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.1.91"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110034"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.77.1.54"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00709.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510368650"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:04:41Z","timestamp":1696248281000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,16]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jre.12123"],"URL":"https:\/\/doi.org\/10.1111\/jre.12123","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,16]]}}}