{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:21:20Z","timestamp":1790083280277,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The goal of the present study was to evaluate the effects of systemic boric acid on the levels of expression of <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> and osteoprotegerin (<jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>) and on histopathologic and histometric changes in a rat periodontitis model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010four Wistar rats were divided into three groups of eight animals each: nonligated (<jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content>); ligature only (<jats:styled-content style=\"fixed-case\">LO<\/jats:styled-content>); and ligature plus treatment with boric acid (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) (3\u00a0mg\/kg per day for 11\u00a0d). A 4\/0 silk suture was placed in a subgingival position around the mandibular right first molars; after 11\u00a0d the rats were killed, and alveolar bone loss in the first molars was histometrically determined. Periodontal tissues were examined histopathologically to assess the differences among the study groups. <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content> were detected immunohistochemically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alveolar bone loss was significantly higher in the <jats:styled-content style=\"fixed-case\">LO<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The number of inflammatory infiltrate and osteoclasts in the <jats:styled-content style=\"fixed-case\">LO<\/jats:styled-content> group was significantly higher than that in the <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The numbers of osteoblasts in LO and BA groups were significantly higher compared with NL group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). There were significantly more RANKL\u2010positive cells in the LO group than in the BA and NL groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). There was a higher number of <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\u2010positive cells in the <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">LO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study shows that systemic administration of boric acid may reduce alveolar bone loss by affecting the <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content> balance in periodontal disease in rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12126","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T13:50:16Z","timestamp":1377784216000},"page":"472-479","source":"Crossref","is-referenced-by-count":17,"title":["Boric acid inhibits alveolar bone loss in rats by affecting <scp>RANKL<\/scp> and osteoprotegerin expression"],"prefix":"10.1111","volume":"49","author":[{"given":"M.","family":"Sa\u011flam","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Izmir Katip Celebi University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hatipo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Akdeniz University Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"K\u00f6seo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Izmir Katip Celebi University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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