{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:23Z","timestamp":1788870263489,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation for Research Support of State of S\u00e3o Paulo","award":["2003\/10424-0"],"award-info":[{"award-number":["2003\/10424-0"]}]},{"name":"Foundation for Research Support of State of S\u00e3o Paulo","award":["2009\/08773-3"],"award-info":[{"award-number":["2009\/08773-3"]}]},{"name":"Coordination of Improvement of Higher Education Students of the Brazilian Ministry of Education"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>\n                      Although chronic periodontitis (\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      ) is a multifactorial condition, few studies have investigated the potential association of gene variants with the outcome of periodontal therapy. In a previous study, we reported that variants in the\n                      <jats:italic>interleukin<\/jats:italic>\n                      \u2010\n                      <jats:italic>8<\/jats:italic>\n                      (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                        8\n                      <\/jats:italic>\n                      ) gene were associated with\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      in a Brazilian population. The aim of this nonrandomized study was to investigate whether genetic susceptibility to\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      , conferred by the presence of the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                        8\n                      <\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">ATC<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TTC<\/jats:styled-content>\n                      haplotype, influences the clinical outcomes of nonsurgical periodontal therapy and the\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 protein levels in the gingival crevicular fluid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one individuals were grouped according to the presence (susceptible to\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      ;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021) or absence (not susceptible to\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      ;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) of the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                        8\n                      <\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">ATC<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TTC<\/jats:styled-content>\n                      haplotype. These individuals received nonsurgical periodontal therapy from one periodontist, who was blinded to the genetic status of each patient, and follow up continued for 45\u00a0d. The clinical parameters and gingival crevicular fluid samples were collected at baseline and on day 45. The\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 levels were determined by an\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      . The data were subjected to the Mann\u2010Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test, Wilcoxon and Spearman tests and to multiple logistic\u2010regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences between patients with or without the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                        8\n                      <\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">ATC<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TTC<\/jats:styled-content>\n                      haplotype were found for the outcome of nonsurgical periodontal therapy and\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 levels. The multiple logistic\u2010regression analysis did not show a statistically significant association between the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                        8\n                      <\/jats:italic>\n                      haplotype and the variables studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this longitudinal clinical study, we observed that neither the outcome of nonsurgical periodontal therapy nor the\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 levels were influenced by the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                        8\n                      <\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">ATC<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TTC CP<\/jats:styled-content>\n                      \u2010susceptibility haplotype. Additional studies of\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      patients from other ethnic populations are necessary to confirm these results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12128","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T09:50:17Z","timestamp":1377769817000},"page":"489-498","source":"Crossref","is-referenced-by-count":6,"title":["Clinical outcomes of periodontal therapy are not influenced by the\n                    <scp>ATC<\/scp>\n                    \/\n                    <scp>TTC<\/scp>\n                    haplotype in the\n                    <i>\n                      <scp>IL<\/scp>\n                      8\n                    <\/i>\n                    gene"],"prefix":"10.1111","volume":"49","author":[{"given":"S. C. 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H.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Morphology School of Dentistry at Araraquara UNESP\u2010 Univ Estadual Paulista Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry at Araraquara UNESP\u2010 Univ Estadual Paulista Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Secolin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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