{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:01:47Z","timestamp":1758477707890},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background and objective<\/jats:title><jats:p>The subepithelial connective tissue graft (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content>) is the most widely used procedure for the treatment of gingival recession defects. Little is known, however, as to whether the apposed gingival flaps are more predisposed to develop plaque\u2010related inflammation compared to healthy sites. This has salient clinical implications, as the long\u2010term results of root coverage will depend largely on the level of inflammation of the grafted tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present split\u2010mouth case\u2013control study, clinical and biomolecular parameters were used to assess the level of inflammation of periodontal sites 12\u00a0mo after treatment with <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> (test) and healthy non\u2010treated gingivae (control) following the induction of plaque\u2010related gingivitis in 19 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data showed that test sites had a significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) lower gingival index and angulated bleeding score compared to control sites (<jats:styled-content style=\"fixed-case\">gingival index<\/jats:styled-content>\u00a0=\u00a01.05\u00a0\u00b1\u00a00.23 vs. 1.34\u00a0\u00b1\u00a00.47; angulated bleeding score\u00a0=\u00a00.34\u00a0\u00b1\u00a00.37 vs. 0.61\u00a0\u00b1\u00a00.39) after induction of experimental gingivitis, whereas the plaque index did not differ in the two groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). With regard to the biomolecular parameters, baseline levels of the proinflammatory cytokine <jats:styled-content style=\"fixed-case\">interleukin<\/jats:styled-content>\u20101\u03b2 were higher in the gingival crevicular fluid of test sites. However, control sites exhibited more pronounced increase in the levels of <jats:styled-content style=\"fixed-case\">interleukin<\/jats:styled-content>\u20101\u03b2 compared to test sites, upon plaque accumulation, so that the final concentration was similar in both groups. No changes were recorded in the <jats:styled-content style=\"fixed-case\">gingival crevicular fluid volume<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Analysis of the data demonstrates that the sites of gingival recession treated with <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> develop a lower degree of plaque\u2010induced inflammation compared to healthy gingivae. This strongly suggests that <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> does not predispose to inflammation and to further gingival recession and makes it a safe technique in the treatment of gingival defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12133","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:49:36Z","timestamp":1381542576000},"page":"527-535","source":"Crossref","is-referenced-by-count":4,"title":["Unexpected resilience to experimental gingivitis of subepithelial connective tissue grafts in gingival recession defects: a clinical\u2013molecular evaluation"],"prefix":"10.1111","volume":"49","author":[{"given":"A.","family":"Graziano","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental School University of Turin Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Melbourne Dental School &amp; Oral Health CRC The University of Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pallotti","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of Turin Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cricenti","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of Turin Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of Turin Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aimetti","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of Turin Torino 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