{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:35Z","timestamp":1787015615887,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T00:00:00Z","timestamp":1386979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Clorox Company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>The study aimed to evaluate the effect of 0.25% sodium hypochlorite twice\u2010weekly oral rinse on plaque and gingivitis in patients with minimally treated periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      The study included 30 patients with periodontitis, it lasted 3\u00a0mo, and it was performed as a randomized, controlled, single\u2010blinded, clinical trial in parallel groups. Fifteen patients rinsed for 30\u00a0s with 15\u00a0mL of a fresh solution of 0.25% sodium hypochlorite (test) and 15 patients rinsed with 15\u00a0mL of water (control). Clorox\n                      <jats:sup>\u00ae<\/jats:sup>\n                      regular bleach was the source of the sodium hypochlorite. At baseline and at 2\u00a0wk, the study patients received professional subgingival irrigation for 5\u00a0min with either 0.25% sodium hypochlorite or water, but no subgingival or supragingival scaling. The presence or absence of supragingival plaque on facial and lingual surfaces was determined by visual inspection; each tooth was dried with air and mouth mirror rotation was used to provide light reflection to identify plaque on smooth surfaces and at the tooth line angles. Gingival bleeding within 30\u00a0s after probing to full pocket depth was assessed in six sites of each tooth. Adverse events were evaluated by questionnaire and visual examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 30 patients in the study completed the baseline and the 2\u00a0wk parts of the study and a subset of 12 participants completed the 3\u00a0mo part of the study. The sodium hypochlorite rinse group and the water rinse group, respectively, showed increases from baseline to 3\u00a0mo of 94% and 29% (3.2\u2010fold difference) in plaque\u2010free facial surfaces, of 195% and 30% (6.5\u2010fold difference) in plaque\u2010free lingual surfaces, and of 421% and 29% (14.5\u2010fold difference) in number of teeth with no bleeding on probing. The differences in clinical improvement between the sodium hypochlorite rinse group and the water rinse group were statistically significant. No adverse events were identified in any of the study patients, except for minor complaints about the taste of bleach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A twice\u2010weekly oral rinse with 0.25% sodium hypochlorite produced marked decreases in dental plaque level and bleeding on probing and may constitute a promising new approach to the management of periodontal disease. Long\u2010term controlled studies on the effectiveness of sodium hypochlorite oral rinse are needed and encouraged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12151","type":"journal-article","created":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T00:54:54Z","timestamp":1386982494000},"page":"696-702","source":"Crossref","is-referenced-by-count":52,"title":["Periodontal effects of 0.25% sodium hypochlorite twice\u2010weekly oral rinse. A pilot study"],"prefix":"10.1111","volume":"49","author":[{"given":"M.","family":"Galv\u00e1n","sequence":"first","affiliation":[{"name":"Graduate Periodontology Clinic Ostrow School of Dentistry of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Clinic Ostrow School of Dentistry of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Clinic Ostrow School of Dentistry of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. A.","family":"Alonaizan","sequence":"additional","affiliation":[{"name":"Graduate Endodontic Clinic Ostrow School of Dentistry of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. T\u2010L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Clinic Ostrow School of Dentistry of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K.","family":"Rich","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Clinic Ostrow School of Dentistry of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Slots","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Clinic Ostrow School of Dentistry of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00429.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.1.147"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-102912-142520"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0738-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-12-00322"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.434"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12150"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2008.tb00354.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.9.564"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2011.00111.x"},{"key":"e_1_2_6_12_1","first-page":"326","volume-title":"Accepted Dental Therapeutics","author":"American Dental Association","year":"1984"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-8-200104170-00012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.1.171-174.1999"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01972.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00656.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb02174.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00514.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027009637.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00308.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01043.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1996.tb00080.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.02.005"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:17:13Z","timestamp":1696238233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,14]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/jre.12151"],"URL":"https:\/\/doi.org\/10.1111\/jre.12151","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,14]]}}}