{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:41:45Z","timestamp":1791416505040,"version":"4.3.3"},"reference-count":88,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education Malaysia","doi-asserted-by":"crossref","award":["HIR\/MOHE\/DENT\/04"],"award-info":[{"award-number":["HIR\/MOHE\/DENT\/04"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001827","name":"University of Amsterdam","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001827","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    Studies to elucidate the role of genetics as a risk factor for periodontal disease have gone through various phases. In the majority of cases, the initial \u2018hypothesis\u2010dependent\u2019 candidate\u2010gene polymorphism studies did not report valid genetic risk loci. Following a large\u2010scale replication study, these initially positive results are believed to be caused by type 1 errors. However, susceptibility genes, such as CDKN2BAS (Cyclin Dependend KiNase 2B AntiSense RNA; alias\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">ANRIL<\/jats:styled-content>\n                    <\/jats:italic>\n                    [ANtisense Rna In the Ink locus])\n                    <jats:italic>,<\/jats:italic>\n                    glycosyltransferase 6 domain containing 1 (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GLT<\/jats:styled-content>\n                      6D1\n                    <\/jats:italic>\n                    ) and cyclooxygenase 2 (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    ), have been reported as conclusive risk loci of periodontitis. The search for genetic risk factors accelerated with the advent of \u2018hypothesis\u2010free\u2019 genome\u2010wide association studies (\n                    <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>\n                    ). However, despite many different\n                    <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>\n                    being performed for almost all human diseases, only three\n                    <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>\n                    on periodontitis have been published \u2013 one reported genome\u2010wide association of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GLT<\/jats:styled-content>\n                      6D1\n                    <\/jats:italic>\n                    with aggressive periodontitis (a severe phenotype of periodontitis), whereas the remaining two, which were performed on patients with chronic periodontitis, were not able to find significant associations. This review discusses the problems faced and the lessons learned from the search for genetic risk variants of periodontitis. Current and future strategies for identifying genetic variance in periodontitis, and the importance of planning a well\u2010designed genetic study with large and sufficiently powered case\u2013control samples of severe phenotypes, are also discussed.\n                  <\/jats:p>","DOI":"10.1111\/jre.12167","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T07:02:45Z","timestamp":1392620565000},"page":"683-695","source":"Crossref","is-referenced-by-count":45,"title":["Moving into a new era of periodontal genetic studies: relevance of large case\u2013control samples using severe phenotypes for genome\u2010wide association studies"],"prefix":"10.1111","volume":"49","author":[{"given":"R. D.","family":"Vaithilingam","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Department of Restorative Dentistry University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Safii","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Restorative Dentistry University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Baharuddin","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Restorative Dentistry University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Ng","sequence":"additional","affiliation":[{"name":"Faculty of Science Institute of Biological Science University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Cheong","sequence":"additional","affiliation":[{"name":"Oral Cancer Research Team Cancer Research Initiatives Foundation Sime Darby Medical Centre Selangor Malaysia"},{"name":"Faculty of Dentistry Department of Oral\u2010maxillofacial Surgical and Medical Sciences University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Bartold","sequence":"additional","affiliation":[{"name":"Department of Dentistry Colgate Australian Clinical Dental Research Centre University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. G.","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.13"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00415.x"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080220"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00450.x"},{"key":"e_1_2_16_9_1","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. 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