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The aim of this study was to assess high\u2010sensitivity C\u2010reactive protein (HsCRP) and lipid levels in healthy adults and patients with coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>), with and without periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 100 subjects were included in the study and categorized into four groups of 25 subjects each, as follows: subjects with chronic periodontitis with angiographically proven <jats:styled-content style=\"fixed-case\">CAD;<\/jats:styled-content> nonperiodontitis subjects with angiographically proven <jats:styled-content style=\"fixed-case\">CAD;<\/jats:styled-content> otherwise healthy subjects with only <jats:styled-content style=\"fixed-case\">chronic periodontitis;<\/jats:styled-content> and systemically and orally healthy individuals. The periodontal parameters measured included plaque index, gingival index, probing pocket depth, clinical attachment level and marginal alveolar bone loss (which was recorded radiographically). Serum samples were collected for estimation of Hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>), high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) and triglycerides (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum Hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels in subjects with either <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> or chronic periodontitis were elevated two\u2010fold compared with those of healthy individuals, whereas in subjects with both diseases (<jats:styled-content style=\"fixed-case\">CAD plus<\/jats:styled-content> chronic periodontitis) the levels were elevated three\u2010fold. The serum <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> level was higher, and the serum <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> level was lower, in all the test groups compared with the healthy group. No significant difference among the groups was detected in the <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A persistent infection, such as chronic periodontitis, may influence changes in the systemic levels of Hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LDL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HDL,<\/jats:styled-content> which potentially have an impact on inflammation\u2010associated atherosclerotic processes, such as <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12172","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T13:48:53Z","timestamp":1394632133000},"page":"836-844","source":"Crossref","is-referenced-by-count":22,"title":["Assessment of high\u2010sensitivity C\u2010reactive protein and lipid levels in healthy adults and patients with coronary artery disease, with and without periodontitis \u2013 a cross\u2010sectional study"],"prefix":"10.1111","volume":"49","author":[{"given":"K. 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