{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:18:54Z","timestamp":1791332334637,"version":"4.3.1"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The purpose of this article was to summarize what is known about the function of melatonin in the oral cavity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Databases were searched for the relevant published literature to 30 November, 2013. The following search items were used in various combinations: melatonin, gingiva, periodontium, inflammation, herpes, alveolar bone, periodontal ligament, dental implants, xerostomia, methacrylate, chlorhexidine, cancer. The literature uncovered is summarized herein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Salivary melatonin levels exhibit a circadian rhythm with highest values at night. Melatonin has both receptor\u2010mediated and receptor\u2010independent actions in cells of the oral cavity. Melatonin is released into the saliva by the acinar cells of the major salivary glands and via the gingival fluid. Functions of melatonin in the oral cavity are likely to relate primarily to its anti\u2010inflammatory and antioxidant activities. These actions may suppress inflammation of the gingiva and periodontium, reduce alveolar bone loss, abrogate herpes lesions, enhance osteointegration of dental implants, limit oral cancer, and suppress disorders that have a free radical component. Sublingual melatonin tablets or oral melatonin sprays and topical melatonin\u2010containing gel, if used on a regular basis, may improve overall oral health and reduce mucosal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, the results indicate that endogenously\u2010produced and exogenously\u2010applied melatonin are beneficial to the oral cavity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12176","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T12:07:03Z","timestamp":1395749223000},"page":"9-17","source":"Crossref","is-referenced-by-count":77,"title":["Melatonin in the oral cavity: physiological and pathological implications"],"prefix":"10.1111","volume":"50","author":[{"given":"R. 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