{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T09:21:17Z","timestamp":1778404877974,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Foundation of Gazi University","award":["03\/2006-19"],"award-info":[{"award-number":["03\/2006-19"]}]},{"name":"Scientific Research Foundation of Gazi University","award":["no. 03\/2006-19"],"award-info":[{"award-number":["no. 03\/2006-19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Objectives<\/jats:title>The purpose of this study was to evaluate the gingival crevicular fluid levels of interleukin\u20101beta (IL<\/jats:styled-content>\u20101\u03b2), matrix metalloproteinases\u20103 (MMP<\/jats:styled-content>\u20103), tissue type plasminogen activator (t\u2010PA<\/jats:styled-content>) and plasminogen activator inhibitor 2 (PAI<\/jats:styled-content>\u20102) in patients with chronic periodontitis, aggressive periodontitis (AgP) and healthy individuals (controls).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Systemically healthy (21 chronic periodontitis<\/jats:styled-content>, 23 AgP and 20 controls) subjects were included in this study. Plaque index, gingival index, probing pocket depth and clinical attachment level were recorded and gingival crevicular fluid<\/jats:styled-content> samples were collected. Assays for IL<\/jats:styled-content>\u20101\u03b2, MMP<\/jats:styled-content>\u20103, t\u2010PA<\/jats:styled-content> and PAI<\/jats:styled-content>\u20102 levels in gingival crevicular fluid were carried out by an enzyme\u2010linked immunosorbent assay. The one\u2010sample Kolmogorov\u2013Smirnov test, Mann\u2013Whitney U<\/jats:italic> test and Spearman correlation coefficient were used for data analyses.<\/jats:p><\/jats:sec>Results<\/jats:title>Gingival crevicular fluid levels of t\u2010PA<\/jats:styled-content> and IL<\/jats:styled-content>\u20101\u03b2 were significantly higher in chronic periodontitis<\/jats:styled-content> and AgP groups than in the control group (p<\/jats:italic>\u00a0<\u00a00.001). MMP<\/jats:styled-content>\u20103 levels in gingival crevicular fluid were detected as significantly higher in the chronic periodontitis<\/jats:styled-content> and AgP groups compared with the control group (p<\/jats:italic>\u00a0<\u00a00.05). The t\u2010PA<\/jats:styled-content>\/PAI<\/jats:styled-content>\u20102 rate of patients with chronic periodontitis<\/jats:styled-content> and AgP were significantly higher than the control group (p<\/jats:italic>\u00a0<\u00a00.05). The positive correlations were found among the PAI<\/jats:styled-content>\u20102, t\u2010PA<\/jats:styled-content>, IL<\/jats:styled-content>\u20101\u03b2 and MMP<\/jats:styled-content>\u20103 levels in gingival crevicular fluid. The volume of the gingival crevicular fluid<\/jats:styled-content> correlated with all of the clinical parameters (p<\/jats:italic>\u00a0<\u00a00.001). There were positive correlations between the gingival crevicular fluid levels of PAI<\/jats:styled-content>\u20102 and the probing pocket depth<\/jats:styled-content> and between gingival crevicular fluid<\/jats:styled-content> levels of PAI<\/jats:styled-content>\u20102 and the clinical attachment level<\/jats:styled-content> (p<\/jats:italic>\u00a0<\u00a00.01). Similarly, significant correlations were found between t\u2010PA<\/jats:styled-content> levels and probing pocket depth<\/jats:styled-content> and between t\u2010PA<\/jats:styled-content> levels and clinical attachment level<\/jats:styled-content> measurements (p<\/jats:italic>\u00a0<\u00a00.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The present data showed that gingival crevicular fluid<\/jats:styled-content> levels of IL<\/jats:styled-content>\u20101 \u03b2, MMP<\/jats:styled-content>\u20103 and t\u2010PA<\/jats:styled-content> increased in periodontal disease regardless of the periodontitis type and played a part in tissue destruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12179","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T07:28:41Z","timestamp":1396423721000},"page":"44-51","source":"Crossref","is-referenced-by-count":40,"title":["Evaluation of gingival crevicular fluid levels of tissue plasminogen activator, plasminogen activator inhibitor 2, matrix metalloproteinase\u20103 and interleukin 1\u2010\u03b2 in patients with different periodontal diseases"],"prefix":"10.1111","volume":"50","author":[{"given":"U.","family":"Toyman","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Gazi University Ankara Turkey"},{"name":"The Health Ministry Center of Oral and Dental Health Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"T\u00fcter","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kurti\u015f","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"K\u0131vrak","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e.","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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