{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:55:56Z","timestamp":1768917356363,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Although regenerative periodontal surgery with <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> or guided tissue regeneration (<jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content>) has been shown to enhance periodontal regeneration, there are limited data on the long\u2010term results following these treatment modalities. The purpose of the present study was to investigate the long\u2010term clinical outcomes in intrabony defects following regenerative periodontal surgery with <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> compared with open\u2010flap debridement (<jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Data from 40 subjects (44 teeth), with no history of smoking or systemic diseases that could interfere with periodontal disease and who received one of three surgical procedures (<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GTR<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content>) for two\u2010 or three\u2010wall intrabony defects, were analyzed. Postoperative reduction in probing pocket depth, gain in clinical attachment level, gingival recession and percentage bone fill were compared at 1, 3 and 5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reduction in <jats:styled-content style=\"fixed-case\">probing pocket depth<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> was significantly higher than after <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content> at 1 and 3\u00a0years postoperatively, but there was no difference between the groups at 5\u00a0years. The gains in <jats:styled-content style=\"fixed-case\">clinical attachment level<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> (at 3 and 5\u00a0years) and for <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> (at 1, 3 and 5\u00a0years) were significantly greater than for <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">Gingival recession<\/jats:styled-content> after treatment with <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> showed a tendency toward positive results, whereas no such tendency was observed for <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content>. Postoperative percentage bone fill for <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> was significantly greater than for <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content> at 3 and 5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is a retrospective study and an exploratory report with a high risk of bias. Within the limits of the current study, it may be concluded that superior gains in <jats:styled-content style=\"fixed-case\">clinical attachment level<\/jats:styled-content> and improved percentage bone fill can be obtained with <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> when compared with <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content>, and these can be maintained over a period of 5\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12188","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T09:39:54Z","timestamp":1399887594000},"page":"123-130","source":"Crossref","is-referenced-by-count":13,"title":["Five\u2010year clinical results for treatment of intrabony defects with EMD, guided tissue regeneration and open\u2010flap debridement: a case 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