{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:51:27Z","timestamp":1783421487808,"version":"3.54.6"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,12]],"date-time":"2014-07-12T00:00:00Z","timestamp":1405123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Background and Objective<\/jats:title>Previous systematic reviews have reported that the use of a coronally advanced flap (CAF<\/jats:styled-content>) combined with a connective tissue graft (CTG<\/jats:styled-content>) or enamel matrix derivative (EMD<\/jats:styled-content>) is more likely to achieve complete root coverage (CRC<\/jats:styled-content>) than other modalities. However, the details of periodontal parameters and comparisons among a variety of combinations of CAF<\/jats:styled-content> with CTG<\/jats:styled-content> and\/or EMD<\/jats:styled-content> are left to be investigated. This study aimed to analyze the differences in periodontal parameters between these treatment modalities.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>A literature search was performed using the C<\/jats:styled-content>ochrane library and MEDLINE<\/jats:styled-content> (P<\/jats:styled-content>ubM<\/jats:styled-content>ed) for studies focused on the treatment of gingival recession (M<\/jats:styled-content>iller C<\/jats:styled-content>lass I<\/jats:styled-content>, II<\/jats:styled-content> and III<\/jats:styled-content>) with CAF<\/jats:styled-content> alone or combined with CTG<\/jats:styled-content>, EMD<\/jats:styled-content> or both up to D<\/jats:styled-content>ecember 2011. Randomized controlled clinical trials with a follow\u2010up duration \u2265\u00a06\u00a0mo were included. The outcome analysis included changes in periodontal probing depth (PPD<\/jats:styled-content>), clinical attachment level, recession depth (RED<\/jats:styled-content>) and keratinized tissue width (KTW<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Thirteen randomized controlled clinical trial<\/jats:styled-content>s, including 529 M<\/jats:styled-content>iller C<\/jats:styled-content>lass I<\/jats:styled-content>\u2013III<\/jats:styled-content> defects from 321 patients were included. For an increase in KTW<\/jats:styled-content>, CAF<\/jats:styled-content> + CTG<\/jats:styled-content> significantly improved more than CAF<\/jats:styled-content> alone. CAF<\/jats:styled-content> + EMD<\/jats:styled-content> also gained more KTW<\/jats:styled-content> than CAF<\/jats:styled-content> alone. EMD<\/jats:styled-content> reduced PPD<\/jats:styled-content>, however, a significant difference was not found. Furthermore, the effects on changes of RED<\/jats:styled-content> and clinical attachment level<\/jats:styled-content> were not identified in the study.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>When combined with CAF<\/jats:styled-content>, CTG<\/jats:styled-content> contributed more in the increase of KTW<\/jats:styled-content>, while EMD<\/jats:styled-content> seemed helpful for wound healing by its potential in PPD<\/jats:styled-content> reduction. However, further research is needed to clarify the effects on changes in RED<\/jats:styled-content> and clinical attachment level<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12199","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T15:13:39Z","timestamp":1405437219000},"page":"220-230","source":"Crossref","is-referenced-by-count":32,"title":["Root coverage by coronally advanced flap with connective tissue graft and\/or enamel matrix derivative: a meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"G.\u2010L.","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center Tri\u2010Service, General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center Tri\u2010Service, General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010K.","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology & Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.\u2010C.","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dentistry Buddhist Tzu Chi General Hospital, Taipei Branch Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010C.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center Tri\u2010Service, General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.\u2010Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center Tri\u2010Service, General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u2010Y.","family":"Yuh","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center Tri\u2010Service, General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010Y.","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center Tri\u2010Service, General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.489"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.303"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.671"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.11.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.4.206"},{"key":"e_1_2_5_7_1","first-page":"472","article-title":"The transpositioned flap in mucogingival surgery","volume":"10","author":"Bahat O","year":"1990","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1968.39.2.65"},{"key":"e_1_2_5_9_1","first-page":"187","article-title":"Acute necrotizing gingivitis","volume":"13","author":"Grupe HE","year":"1956","journal-title":"Med Bull US Army Eur"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1977.48.1.41"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.4.305"},{"key":"e_1_2_5_12_1","first-page":"180","article-title":"Management of advanced periodontitis. 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