{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:49:21Z","timestamp":1781005761395,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,12]],"date-time":"2014-07-12T00:00:00Z","timestamp":1405123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International Association for Dental Research - Continental European Division"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>L\u2010plastin, an actin\u2010bundling protein, is exclusively expressed in leukocytes and plays a crucial role in immune\u2010mediated events. Periodontitis is a common infectious inflammatory disease that destroys the tooth\u2010supporting tissues. Recent findings using proteomic technologies have demonstrated that L\u2010plastin is one of the few molecules consistently present in the inflammatory exudate of the gingiva in periodontal disease, but not in health. Therefore, this study aimed to investigate in detail the local and systemic role of this molecule in different forms of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 61 subjects who met the inclusion\/exclusion criteria were recruited, including 21 with chronic periodontitis, 20 generalized aggressive periodontitis and 20 nonperiodontitis control subjects. Gingival tissue biopsies, gingival crevicular fluid, as well as serum and saliva, were obtained. Immunohistochemistry and quantitative real\u2010time PCR were employed to evaluate the localization and m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression, respectively, of L\u2010plastin. L\u2010plastin levels in gingival crevicular fluid, saliva and serum were measured using ELISA. Statistical analysis was performed using nonparametric methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects with chronic periodontitis and generalized aggressive periodontitis exhibited significantly higher tissue L\u2010plastin gene expression and gingival crevicular fluid levels than did subjects in the control group but there was no significant difference between the two forms of periodontitis. Within gingival tissue, L\u2010plastin was confined to the inflammatory infiltrate. There was no statistically significant difference between serum and salivary L\u2010plastin levels among the three study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The elevated gingival tissue expression and gingival crevicular fluid levels of L\u2010plastin in both forms of periodontitis may denote the localized involvement of this novel molecule in the pathogenesis of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12212","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T15:14:03Z","timestamp":1405437243000},"page":"337-346","source":"Crossref","is-referenced-by-count":17,"title":["The actin\u2010bundling protein L\u2010plastin: a novel local inflammatory marker associated with periodontitis"],"prefix":"10.1111","volume":"50","author":[{"given":"V. \u00d6.","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Oral Translational Research Institute of Oral Biology Center of Dental Medicine University of Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Department of Periodontology School of Dentistry Ege University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Emingil","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Osterwalder","sequence":"additional","affiliation":[{"name":"Oral Translational Research Institute of Oral Biology Center of Dental Medicine University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Oral Translational Research Institute of Oral Biology Center of Dental Medicine University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00191.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00821.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2009.0864"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.6.545"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00353.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.32"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400252"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53842-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/213492"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.6.1995"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00145.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/935173"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6047"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advenzreg.2006.12.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00172-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9331"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001424"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01678.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr900941z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130144"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300761e"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.099697"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100446f"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13044642"},{"key":"e_1_2_7_29_1","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. A summary of current work","volume":"34","author":"Page RC","year":"1976","journal-title":"Lab Invest"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01948.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03972.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00354.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513506011"},{"key":"e_1_2_7_34_1","first-page":"5643","article-title":"Abundant synthesis of the transformation\u2010induced protein of neoplastic human fibroblasts, plastin, in normal lymphocytes","volume":"45","author":"Goldstein D","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2006.tb03801.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101033"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103242"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2007.006230"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100236r"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1678-4"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:32:32Z","timestamp":1696519952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,12]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/jre.12212"],"URL":"https:\/\/doi.org\/10.1111\/jre.12212","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,12]]}}}