{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:28:12Z","timestamp":1761823692802},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T00:00:00Z","timestamp":1406332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p><jats:italic>Porphyromonas gingivalis<\/jats:italic> (Pg) lipopolysaccharide is associated with the immune response and atherosclerosis. This study aimed to evaluate the effects of micro\u2010amounts of Pg\u2010lipopolysaccharide on rabbit inflammatory immune response and the development of atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010four New Zealand white rabbits were randomly divided into four groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a06). Group A was fed a regular diet and normal saline. Group B was supplied with a high\u2010fat diet and normal saline. Group C was treated with a normal diet and Pg\u2010lipopolysaccharide. Group D was given a high\u2010fat diet and Pg\u2010lipopolysaccharide. After 14\u00a0wk, the rabbits were killed to determine the changes in pathological indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum lipid levels of groups B and D were significantly higher than that of group A (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), and that of group C was higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Serum interleukin\u20106, monocyte chemoattractant protein\u20101 and tumor necrosis factor\u2010\u03b1 levels were significantly elevated by individual high\u2010fat diets or Pg\u2010lipopolysaccharide stimulation (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Groups A and C did not undergo evident aortic pathological damages, while foam cells appeared in the other two groups. Real\u2010time polymerase chain reaction detection showed that toll\u2010like receptor\u20102, interleukin\u20106, matrix metalloproteinase\u20109 and monocyte chemoattractant protein\u20101 were highly expressed in groups B and D (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and toll\u2010like receptor\u20104, C\u2010reactive protein and tumor necrosis factor\u2010\u03b1 levels were higher than those of group A (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Western blotting showed that transcription factor NF\u2010\u03baB p65 was expressed more highly in the three experimental groups than in group A (<jats:italic>t<\/jats:italic>\u00a0=\u00a09.26, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Micro\u2010amounts of Pg\u2010lipopolysaccharide induced the high expressions of inflammatory factors and mediated the inflammatory response. Pg\u2010lipopolysaccharide elevated the blood lipid level less significantly than the high\u2010fat diet did, but it may promote atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12214","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T07:48:47Z","timestamp":1406360927000},"page":"356-362","source":"Crossref","is-referenced-by-count":7,"title":["Effects of micro\u2010amounts of <i>Porphyromonas gingivalis<\/i> lipopolysaccharide on rabbit inflammatory immune response and development of atherosclerosis"],"prefix":"10.1111","volume":"50","author":[{"given":"G.","family":"Lin","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"},{"name":"Department of Stomatology Fujian Provincial People's Hospital Fujian University of Traditional Chinese Medicine Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Shi","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chen","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lei","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"You","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Huang","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Luo","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Yan","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University, and Stomatological Key Laboratory of Fujian College and University Fuzhou China"},{"name":"School and Hospital of Stomatology Fujian Medical University Fuzhou Fujian China"},{"name":"School of Stomatology Nanjing University Nanjing Stomatological Hospital Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01741.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01500.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300315"},{"key":"e_1_2_10_5_1","first-page":"23","article-title":"Microorganisms as risks for indicators for periodontal diseases","volume":"32","author":"Ezzo PJ","year":"2000","journal-title":"Peridontol 2000"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00600-10"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012673"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.05.021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.79"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.04.002"},{"key":"e_1_2_10_11_1","unstructured":"ARRIVE guidelines. Animal Research: Reporting of In Vivo Experiments. Available at:http:\/\/www.nc3rs.org.uk\/page.asp?id=1357."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710335105"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.611"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2006.01.016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-011-1415-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01775.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31825719f3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340019"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:31:48Z","timestamp":1696519908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,26]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/jre.12214"],"URL":"https:\/\/doi.org\/10.1111\/jre.12214","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,26]]}}}