{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:34:47Z","timestamp":1770820487392,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The aim of this study was to compare the levels of levels of interleukin\u201037 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201037) in gingival crevicular fluid, saliva and plasma in patients with periodontal disease and patients with healthy periodontium and to correlate these levels with clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Samples of gingival crevicular fluid, whole saliva and plasma were collected from systemically healthy, nonsmoker periodontally healthy controls (group 1, <jats:italic>n<\/jats:italic>\u00a0=\u00a020), gingivitis patients (group 2, <jats:italic>n<\/jats:italic>\u00a0=\u00a020) and chronic periodontitis patients (group 3, <jats:italic>n<\/jats:italic>\u00a0=\u00a020). Full\u2010mouth clinical periodontal parameters, including probing depth, plaque index, gingival index and bleeding on probing, were also recorded. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201037 levels in the biofluid samples were determined by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Data were tested statistically using the Kruskal\u2013Wallis test followed by the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentration of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201037 in gingival crevicular fluid was significantly lower in group 3 than in groups 1 and 2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), whereas the total amounts in <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> samples were similar (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). The salivary and plasma concentrations of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201037 were similar in the study groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). There were negative correlations between <jats:styled-content style=\"fixed-case\">gingival crevicular fluid IL<\/jats:styled-content>\u201037 concentrations and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> volume in all groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). There was also a negative correlation between the <jats:styled-content style=\"fixed-case\">gingival crevicular fluid IL<\/jats:styled-content>\u201037 concentration and <jats:styled-content style=\"fixed-case\">gingival index<\/jats:styled-content> in group 3 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IL\u201037 was expressed in all biofluids. According to our findings, the total amount of IL\u201037 in gingival crevicular fluid, or salivary or plasma concentrations of IL\u201037, may not be useful diagnostic markers to differentiate periodontal disease and the periodontally healthy condition. The difference in gingival crevicular fluid IL\u201037 concentration between the study groups may be a result of the variation in gingival crevicular fluid volume, as suggested by the negative correlation between gingival crevicular fluid volume and gingival crevicular fluid IL\u201037 concentration. In the light of our findings, it seems that IL\u201037 is not involved in periodontal disease. Further comprehensive studies may clarify this issue more clearly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12241","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T05:45:47Z","timestamp":1416203147000},"page":"614-621","source":"Crossref","is-referenced-by-count":13,"title":["Levels of interleukin\u201037 in gingival crevicular fluid, saliva, or plasma in periodontal disease"],"prefix":"10.1111","volume":"50","author":[{"given":"M.","family":"Sa\u011flam","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Izmir Katip Celebi University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"K\u00f6seo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Izmir Katip Celebi University Izmir 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