{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:27:53Z","timestamp":1792798073037,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:00:00Z","timestamp":1423267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ankara University Scientific Research Projects Office","award":["08B3334005"],"award-info":[{"award-number":["08B3334005"]}],"id":[{"id":"https:\/\/ror.org\/01wntqw50","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Inflammation is associated with hydroxyl radical damage to\n                      <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                      as a result of oxidative stress. 8\u2010Hydroxy deoxyguanosine (8\u2010\n                      <jats:styled-content style=\"fixed-case\">OHdG<\/jats:styled-content>\n                      ) is a marker of this process and its levels in saliva could be linked to the severity of periodontal inflammation. The aim of this study was to test the sensitivity of liquid chromatography with tandem mass spectrometry (\n                      <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">MS)<\/jats:styled-content>\n                      in comparison to enzyme\u2010linked immune sorbent assay (\n                      <jats:styled-content style=\"fixed-case\">ELISA)<\/jats:styled-content>\n                      for the detection of 8\u2010\n                      <jats:styled-content style=\"fixed-case\">OHdG<\/jats:styled-content>\n                      in saliva in patients with chronic periodontitis before and after periodontal treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Saliva samples were collected from 23 patients (eight females and 15 males; 46.1\u00a0\u00b1\u00a05.1\u00a0years of age) with generalized chronic periodontitis and 25 (15 females and 10 males; 44.9\u00a0\u00b1\u00a06.8\u00a0years of age) periodontally healthy individuals. Patients received initial periodontal treatment consisting of scaling and root planing and were evaluated at baseline and after 6\u00a0wk of completion of non\u2010surgical therapy. Salivary 8\u2010\n                      <jats:styled-content style=\"fixed-case\">OHdG<\/jats:styled-content>\n                      levels were measured using\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      before and after the treatment. Clinically, plaque index, gingival index, clinical attachment level, bleeding on probing, gingival recession and probing pocket depth were measured at baseline and after 6\u00a0wk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Salivary levels of 8\u2010\n                      <jats:styled-content style=\"fixed-case\">OHdG<\/jats:styled-content>\n                      decreased significantly after the non\u2010surgical periodontal treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Statistically significant positive correlations were observed between plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing values and\n                      <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      levels of 8\u2010\n                      <jats:styled-content style=\"fixed-case\">OHdG<\/jats:styled-content>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      is a reliable and sensitive method for evaluating salivary 8\u2010\n                      <jats:styled-content style=\"fixed-case\">OHdG<\/jats:styled-content>\n                      levels to monitor the treatment response of periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12263","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T02:43:24Z","timestamp":1423277004000},"page":"766-774","source":"Crossref","is-referenced-by-count":33,"title":["High sensitivity detection of salivary 8\u2010hydroxy deoxyguanosine levels in patients with chronic periodontitis"],"prefix":"10.1111","volume":"50","author":[{"given":"\u015e.","family":"Kurgan","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"\u00d6nder","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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