{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:48:43Z","timestamp":1775584123345,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cPro-Reitoria de Pesquisa da UNESP\u201d"},{"DOI":"10.13039\/501100009523","name":"\u201cFUNDUNESP\u201d","doi-asserted-by":"crossref","award":["0468\/011\/14-PROPe\/CDC"],"award-info":[{"award-number":["0468\/011\/14-PROPe\/CDC"]}],"id":[{"id":"10.13039\/501100009523","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>This study assessed the effects of the local use of <jats:italic>Saccharomyces cerevisiae<\/jats:italic> as monotherapy and as an adjuvant to the mechanical treatment of ligature\u2010induced periodontitis in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Periodontitis was induced in 72 rats via the installation of a ligature around the mandibular first molar. After 7\u00a0d, the ligature was removed and the rats were placed in one of the following groups: no treatment (C; <jats:italic>n<\/jats:italic>\u00a0=\u00a018); scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a018); local irrigation with probiotics (<jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a018); and <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> followed by local irrigation with probiotics (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a018). Six rats from each group were killed at 7, 15 and 30\u00a0d. The histological characteristics, alveolar bone loss (<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>) and immunolabeling of tumor necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1), interleukin\u20101beta (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2), interleukin\u201010 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010) and <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content> on the furcation area of the first molar were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> group showed features of acceleration of the tissue\u2010repair process during the entire experiment. On day 15, there was less <jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> group compared with the C group. There were fewer <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\u2010positive cells in the <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> groups at 30\u00a0d. There was less immunostaining for <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 in the <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> groups and less immunostaining for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 in the <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> group. However, there was more immunostaining for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 in the <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> group on day 15.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Local use of the probiotic did not result in any adverse effects on periodontal tissues. When used as monotherapy or as an adjuvant, the probiotic was effective at controlling periodontitis in rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12274","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T12:45:21Z","timestamp":1430138721000},"page":"26-37","source":"Crossref","is-referenced-by-count":58,"title":["Effect of the probiotic <i>Saccharomyces cerevisiae<\/i> on ligature\u2010induced periodontitis in rats"],"prefix":"10.1111","volume":"51","author":[{"given":"V. G.","family":"Garcia","sequence":"first","affiliation":[{"name":"Group of Research and Study on Laser in Dentistry (GEPLO) Division of Periodontics Department of Surgery and Integrated Clinic University Estadual Paulista (UNESP) Ara\u00e7atuba Brazil"},{"name":"Master Course Barretos Dental School University Center of the Educational Foundation of Barretos (UNIFEB) Barretos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. R.","family":"Knoll","sequence":"additional","affiliation":[{"name":"Master Course Barretos Dental School University Center of the Educational Foundation of Barretos (UNIFEB) Barretos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Longo","sequence":"additional","affiliation":[{"name":"Group of Research and Study on Laser in Dentistry (GEPLO) Division of Periodontics Department of Surgery and Integrated Clinic University Estadual Paulista (UNESP) Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. C. N.","family":"Novaes","sequence":"additional","affiliation":[{"name":"Group of Research and Study on Laser in Dentistry (GEPLO) Division of Periodontics Department of Surgery and Integrated Clinic University Estadual Paulista (UNESP) Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Z.","family":"Assem","sequence":"additional","affiliation":[{"name":"Group of Research and Study on Laser in Dentistry (GEPLO) Division of Periodontics Department of Surgery and Integrated Clinic University Estadual Paulista (UNESP) Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Department of Basic Science University Estadual Paulista (UNESP) Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. E. C.","family":"de Toledo","sequence":"additional","affiliation":[{"name":"Master Course Barretos Dental School University Center of the Educational Foundation of Barretos (UNIFEB) Barretos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Theodoro","sequence":"additional","affiliation":[{"name":"Group of Research and Study on Laser in Dentistry (GEPLO) Division of Periodontics Department of Surgery and Integrated Clinic University Estadual Paulista (UNESP) Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"575","article-title":"Clinical and microbiologic effect of nonsurgical periodontal therapy on patients with chronic or aggressive periodontitis","volume":"44","author":"Liu J","year":"2013","journal-title":"Quintessence Int"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01399.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb02309.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.322"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.5s.498"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00453.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14547"},{"key":"e_1_2_7_9_1","volume-title":"Oral Microbiology","author":"Marsh P","year":"1999"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00239.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.926"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v3i0.5304"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.4.222"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1996.tb00068.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0744-6"},{"key":"e_1_2_7_16_1","first-page":"24","article-title":"Efficiency of scaling of the molar furcation area with and without surgical access","volume":"6","author":"Matia JI","year":"1986","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01623.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100195"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120163"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12138"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2011.03132.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01392.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01914.x"},{"key":"e_1_2_7_24_1","first-page":"55","article-title":"Decreased gum bleending and reduced gingivitis by the probiotic Lactobacillus reuteri","volume":"30","author":"Krasse P","year":"2006","journal-title":"Swed Dent J"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01459.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350802516170"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.45"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734406"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01291.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0790-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/jom.v2i0.5344","article-title":"Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial","volume":"2","author":"Vivekananda MR","year":"2010","journal-title":"J Oral Microbiol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734404"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01665.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2004.10.039"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.144485"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1745"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.01.003"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2004.09.013"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601111"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(88)90196-3"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01333.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12164"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120644"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130356"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00672.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080103"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.1.59"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/754857"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01355.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130225"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01172.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010014\u20101575\u20107"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.1009"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2005.00191.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.53763"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400186"},{"key":"e_1_2_7_57_1","volume-title":"Adjunctive Systemic use of Beta\u2010Glucan in the Nonsurgical Treatment of Chronic Periodontitis, Pathogenesis and Treatment of Periodontitis","author":"Acar NN","year":"2012"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.523-533.2000"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-7-5"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.9.579"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.12.750"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.9.820"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10804.x"},{"key":"e_1_2_7_64_1","first-page":"125","article-title":"Effects of macrophages stimulation on collagen biosynthesis in the healing wound","volume":"63","author":"Portera CA","year":"1997","journal-title":"Am Surg"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:11:33Z","timestamp":1695744693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/jre.12274"],"URL":"https:\/\/doi.org\/10.1111\/jre.12274","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,27]]}}}