{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:50:07Z","timestamp":1760889007630},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NSC 97\u2010 2314\u2010B\u2010276\u2010001\u2010MY2","NSC 99\u20102314\u2010B\u2010037\u2010067"],"award-info":[{"award-number":["NSC 97\u2010 2314\u2010B\u2010276\u2010001\u2010MY2","NSC 99\u20102314\u2010B\u2010037\u2010067"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Background and Objective<\/jats:title>The present study investigated the association between the RAGE<\/jats:styled-content> G82S polymorphism, the plasma levels of sRAGE<\/jats:styled-content> and chronic periodontitis in subjects with and without diabetes mellitus (DM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>A total of 230 patients with DM and 264 non\u2010DM<\/jats:styled-content> participants were recruited for this study. Genotyping of the RAGE<\/jats:styled-content> G82S polymorphism was accomplished using polymerase chain reaction\u2013restriction fragment length polymorphism<\/jats:styled-content>, and associations were analyzed with the chi\u2010squared test and logistic regression analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>In the non\u2010DM<\/jats:styled-content> group, the chi\u2010squared test showed that the frequency distributions of the G82S polymorphism were significantly different between chronic periodontitis<\/jats:styled-content> and non\u2010chronic periodontitis<\/jats:styled-content> subjects (\u03c72<\/jats:sup>\u00a0=\u00a08.39, p<\/jats:italic>\u00a0=\u00a00.02). A multivariate logistic regression model showed that the (G82S\u00a0+\u00a0S82S) genotypes were associated with a significantly increased risk of chronic periodontitis<\/jats:styled-content> development compared to the G82G genotype (adjusted odds ratio\u00a0=\u00a02.06, 95% confidence interval: 1.08\u20134.07). In the DM<\/jats:styled-content> group, there was no association between the G82S polymorphism and chronic periodontitis<\/jats:styled-content> development when a multivariate logistic regression was performed. Plasma levels of sRAGE<\/jats:styled-content> were significantly higher in subjects with the G82G genotype compared to those with the (G82S\u00a0+\u00a0S82S) genotypes in both the non\u2010DM<\/jats:styled-content> (856.6\u00a0\u00b1\u00a0332.0 vs. 720.4\u00a0\u00b1\u00a0311.4\u00a0pg\/mL<\/jats:styled-content>, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003) and DM<\/jats:styled-content> groups (915.3\u00a0\u00b1\u00a0497.1 vs. 603.5\u00a0\u00b1\u00a0298.3\u00a0pg\/mL<\/jats:styled-content>, p\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001). However, there was no difference in plasma sRAGE<\/jats:styled-content> levels between chronic periodontitis<\/jats:styled-content> and non\u2010chronic periodontitis<\/jats:styled-content> subjects in both the DM<\/jats:styled-content> and non\u2010DM<\/jats:styled-content> groups. Moreover, when the subjects were further sub\u2010divided by the G82S polymorphism, the difference in plasma levels of sRAGE<\/jats:styled-content> between chronic periodontitis<\/jats:styled-content> and non\u2010chronic periodontitis<\/jats:styled-content> subjects in the DM<\/jats:styled-content> and non\u2010DM<\/jats:styled-content> groups remained statistically insignificant.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The present study revealed that the RAGE<\/jats:styled-content> G82S polymorphism was associated with chronic periodontitis in the non\u2010DM<\/jats:styled-content> group but not in the DM<\/jats:styled-content> group. Our results also showed that the plasma levels of sRAGE<\/jats:styled-content> were significantly higher in subjects with the RAGE<\/jats:styled-content> G82G genotype, and this correlation was not affected by the presence of chronic periodontitis<\/jats:styled-content> in the DM<\/jats:styled-content> and non\u2010DM<\/jats:styled-content> groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12282","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T04:35:45Z","timestamp":1432010145000},"page":"881-889","source":"Crossref","is-referenced-by-count":10,"title":["The association between the RAGE<\/scp> G82S polymorphism, sRAGE<\/scp> and chronic periodontitis in Taiwanese individuals with and without diabetes"],"prefix":"10.1111","volume":"50","author":[{"given":"T.\u2010L.","family":"Wu","sequence":"first","affiliation":[{"name":"School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010C.","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Dentistry Chung\u2010Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010Y.","family":"Ho","sequence":"additional","affiliation":[{"name":"School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010M.","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010C.","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Nursing 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