{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:33:46Z","timestamp":1781145226617,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Many techniques and flap designs have been used to treat gingival recession by root coverage, but subepithelial connective tissue graft (<jats:styled-content style=\"fixed-case\">SCTG)<\/jats:styled-content> seems to be the gold standard procedure. In an attempt to improve the healing process and increase the success rate of root coverage, some authors have used root modifiers, including different root conditioners, lasers, <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>, recombinant human growth factors and platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>). The aim of this systematic review was to evaluate the effects of root biomodification in clinical outcomes of gingival recessions treated with <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Studies reporting <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> associated with any form of root surface biomodification for root coverage of gingival recessions (Miller Class I and Class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) were considered as eligible for inclusion. Studies needed to have data of clinical outcomes in a follow up of at least 6\u00a0months. Screening of the articles, data extraction and quality assessment were conducted independently and in duplicate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the products evaluated (citric acid, <jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PRP<\/jats:styled-content>, lasers and <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) showed evident benefits in clinical outcomes. Test and control groups presented similar outcomes related to root coverage and periodontal parameters, with no statistical differences between them. The exception was root biomodification with the neodymium\u2010doped yttrium aluminium garnet (Nd:<jats:styled-content style=\"fixed-case\">YAG)<\/jats:styled-content> laser, which impaired root coverage and had a detrimental effect on clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the present clinical data, the use of root surface modifiers to improve clinical outcomes in gingival recessions treated with <jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content> is not justified. More <jats:italic>in\u00a0vivo<\/jats:italic> studies, and randomized clinical trials with larger sample sizes and extended follow up, are necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12296","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T17:57:08Z","timestamp":1434736628000},"page":"175-185","source":"Crossref","is-referenced-by-count":32,"title":["Root surface modifiers and subepithelial connective tissue graft for treatment of gingival recessions: a systematic review"],"prefix":"10.1111","volume":"51","author":[{"given":"P. S. B. H.","family":"Karam","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Discipline of Periodontology Bauru Dental School University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. P.","family":"Sant'Ana","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Discipline of Periodontology Bauru Dental School University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L. R.","family":"de Rezende","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Discipline of Periodontology Bauru Dental School University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L. A.","family":"Greghi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Discipline of Periodontology Bauru Dental School University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Damante","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Discipline of Periodontology Bauru Dental School University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S. 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