{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:25:18Z","timestamp":1780496718340,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["TBO\u2010122068"],"award-info":[{"award-number":["TBO\u2010122068"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The relative contribution of genetic and environmental factors to the onset and progression of periodontitis is inconclusive. Despite the high prevalence, phenotypic heterogeneity and significant local and systemic implications of this disease, early detection and individualized therapy are problematic. Using a murine model of periodontitis in a panel of 17 recombinant inbred mice, the current study addressed the heritability of, and oral dysbiosis associated with, inflammation\u2010mediated alveolar bone loss (<jats:styled-content style=\"fixed-case\">iABL<\/jats:styled-content>), the hallmark of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Quantitative trait locus (<jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content>) genomics and quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> for over 99% of known murine oral microbiota were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was found that <jats:styled-content style=\"fixed-case\">iABL<\/jats:styled-content> is a polygenic trait with 32.7% heritability. One suggestive <jats:styled-content style=\"fixed-case\">QTL,<\/jats:styled-content> nicknamed inflammation\u2010mediated alveolar bone loss locus (<jats:styled-content style=\"fixed-case\">iABLL<\/jats:styled-content>), was identified on chromosome 2. Eleven genes involved in innate immune responses and bone metabolism, particularly related to macrophage and osteoblast function, namely <jats:italic>Etl4, Pdss1, Cobll1, 9330158F14Rik, Xirp2, Stk39, Mettl5, Metapl1, Itga6, Pdk1<\/jats:italic> and <jats:italic>Sp3<\/jats:italic>, were found in the <jats:styled-content style=\"fixed-case\">iABLL<\/jats:styled-content> using cis expression <jats:styled-content style=\"fixed-case\">QTL<\/jats:styled-content> and nonsynonymous single nucleotide polymorphism analyses. Specific oral microbiome shifts in saliva and tongue mucosa are associated with disease in this model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that complex host\u2013biofilm interactions generate pathogenic states that extend beyond subgingival biofilms and periodontal tissues. Although no temporal relationship between the onset of <jats:styled-content style=\"fixed-case\">iABL<\/jats:styled-content> and microbiome changes were established, our findings suggest that host factors may be responsible for pathogenic shifts in subgingival biofilms when persistent and undisturbed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12303","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T12:31:33Z","timestamp":1435667493000},"page":"237-249","source":"Crossref","is-referenced-by-count":25,"title":["Identification of quantitative trait loci influencing inflammation\u2010mediated alveolar bone loss: insights into polygenic inheritance of host\u2013biofilm disequilibria in periodontitis"],"prefix":"10.1111","volume":"51","author":[{"given":"C.","family":"Sima","sequence":"first","affiliation":[{"name":"Department of Applied Oral Sciences The Forsyth Institute Cambridge MA USA"},{"name":"Department of Oral Medicine Infection, and Immunity 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