{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:14:34Z","timestamp":1768810474411,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012330","name":"Okayama University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012330","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sunstar Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Background and Objective<\/jats:title>The biochemical effects of an over\u2010the\u2010counter (OTC<\/jats:styled-content>) medication were studied, which consists of a single\u2010tuft brush containing cetylpyridinium chloride as a bactericidal agent, dipotassium glycyrrhizate as an anti\u2010inflammatory drug and allantoin as a promoter of cell proliferation and wound healing, for delivery to hardly brushed sites.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>This randomized controlled double\u2010blind study was performed in 61 subjects with chronic periodontitis in supportive periodontal therapy phase (test group: n<\/jats:italic>\u00a0=\u00a027; placebo group: n<\/jats:italic>\u00a0=\u00a028; dropout: n<\/jats:italic>\u00a0=\u00a06). The OTC<\/jats:styled-content> medication was self\u2010applied twice a day for 12\u00a0wk to two molars with probing pocket depths of 4\u20136\u00a0mm. Biochemical indicators were evaluated at baseline and 12\u00a0wk using the suspension array system for eight cytokines and chemokines (interleukin [IL]<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20101ra, IL<\/jats:styled-content>\u20104, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u20108, IL<\/jats:styled-content>\u201010, monocyte chemoattractant protein<\/jats:styled-content>\u20101 and tumor necrosis factor [TNF]<\/jats:styled-content>\u2010\u03b1) in gingival crevicular fluid.<\/jats:p><\/jats:sec>Results<\/jats:title>The levels of IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u20108 and TNF<\/jats:styled-content>\u2010\u03b1 remained significantly lower in the test group compared to the placebo group. In the placebo group, when the probing pocket depth<\/jats:styled-content> at baseline was 4\u00a0mm, IL<\/jats:styled-content>\u20101\u03b2 increased, particularly in the second molar tooth, and the greatest increase was seen when PPD<\/jats:styled-content> at baseline was 5\u20136\u00a0mm. In the test group, IL<\/jats:styled-content>\u20101\u03b2 decreased markedly in cases with furcation involvement and low bleeding on probing at baseline. In both groups, IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20106 and TNF<\/jats:styled-content>\u2010\u03b1 were closely correlated with each other.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This OTC<\/jats:styled-content> medication is biochemically effective for steady chronic periodontitis in the supportive periodontal therapy<\/jats:styled-content> phase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12311","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T13:58:13Z","timestamp":1438869493000},"page":"321-331","source":"Crossref","is-referenced-by-count":7,"title":["Effects of new over\u2010the\u2010counter periodontal ointment\u2010containing applicator with single\u2010tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double\u2010blind clinical trial"],"prefix":"10.1111","volume":"51","author":[{"given":"K.","family":"Takeuchi\u2010Hatanaka","sequence":"first","affiliation":[{"name":"Department of Pathophysiology\u2010Periodontal Science Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yasuda","sequence":"additional","affiliation":[{"name":"R&D Department of Sunstar Inc. Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Naruishi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2010Periodontal Science Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Katsuragi\u2010Fuke","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2010Periodontal Science Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan"},{"name":"Department of Dentistry National Sanatorium Oshima\u2010Seishoen Takamatsu Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Inubushi","sequence":"additional","affiliation":[{"name":"R&D Department of Sunstar Inc. Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ootsuki","sequence":"additional","affiliation":[{"name":"R&D Department of Sunstar Inc. Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2010Periodontal Science Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Takashiba","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\u2010Periodontal Science Dentistry and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"The American Academy of Periodontology.Supportive treatment. 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