{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:36:21Z","timestamp":1761896181998},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271160","81371151","81470750"],"award-info":[{"award-number":["81271160","81371151","81470750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis has been associated with type 2 diabetes mellitus. We investigated the effects of local aberrant secretion of adipokines in diabetic rats on systemic metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Otsuka Long\u2010Evans Tokushima Fatty (<jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content>) and non\u2010diabetic Long\u2010Evans Tokushima Otsuka rats were used as a diabetic model and associated control, respectively. Periodontitis was induced using a silk ligature for 36 wk. Rats were grouped into <jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content> with (<jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>+) or without (<jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\u2212) periodontitis and Long\u2010Evans Tokushima Otsuka with (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>+) or without (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\u2212) periodontitis. Alveolar bone resorption and destruction were evaluated by micro\u2010computed tomography and hematoxylin and eosin staining. After 20 wk of periodontitis induction, lipids, insulin, interleukin\u20101, leptin and plasminogen activator inhibitor\u20101 were analyzed, and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expressions of <jats:italic><jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB<\/jats:italic>,<jats:italic> Mark8<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> and \u2010<jats:italic>4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">IKBKB<\/jats:styled-content><\/jats:italic> and <jats:italic>Nampt<\/jats:italic> were evaluated by quantitative polymerase chain reaction in adipose tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After ligation, <jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content> rats exhibited typical periodontitis lesions with the clinical features of type 2 diabetes mellitus. When compared with the <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>(\u2212) group, the area under curve of the oral glucose tolerance test and homeostatic model assessment\u2013insulin resistance values were significantly higher in the <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>(+) group. Micro\u2010computed tomography showed that the <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>(+) group had more bone resorption than the <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>(\u2212) group. When compared with the <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>(\u2212) group, the <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>(+) group also exhibited higher total cholesterol (<jats:italic>p<\/jats:italic> &lt; 0.05), leptin (<jats:italic>p<\/jats:italic> &lt; 0.05), insulin (<jats:italic>p<\/jats:italic> &gt; 0.05) and higher expression of <jats:italic>Nampt<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.05) and <jats:italic>IKBKB<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.05). The <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>(+) group had a trend towards higher bone resorption when compared with the <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>(\u2212) group. Additionally, no difference in white adipose tissues or adipokines was found between <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>(+) and <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>(\u2212) rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic periodontitis can alter lipid profiles in affected rats, elevate adipose tissue expression of <jats:italic>Nampt<\/jats:italic> and affect the metabolism of adipose tissue through the <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB pathway to inflame diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12322","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T23:01:35Z","timestamp":1444690895000},"page":"453-461","source":"Crossref","is-referenced-by-count":17,"title":["Periodontitis contributes to aberrant metabolism in type 2 diabetes mellitus rats by stimulating the expression of adipokines"],"prefix":"10.1111","volume":"51","author":[{"given":"S.","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Haizhu District Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Haizhu District Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Haizhu District Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Haizhu District Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Haizhu District Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Haizhu District Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Haizhu District Guangzhou 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