{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:37:25Z","timestamp":1790919445759,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Scaling and root planing are widely considered as effective methods for treating chronic periodontitis. A meta\u2010analysis published in 2008 showed no statistically significant differences between full\u2010mouth disinfection (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>) or full\u2010mouth scaling and root planing (<jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>) and quadrant scaling and root planing (Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> approach only resulted in modest additional improvements in several indices. Whether differences exist between these two approaches requires further validation. Accordingly, a study was conducted to further validate whether <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> with antiseptics or <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> without the use of antiseptics within 24 h provides greater clinical improvement than Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> in patients with chronic periodontitis. Medline (via <jats:styled-content style=\"fixed-case\">OVID<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> (via <jats:styled-content style=\"fixed-case\">OVID<\/jats:styled-content>), PubMed and <jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content> databases were searched up to 27 January 2015. Randomized controlled trials comparing <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> with Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> after at least 3 mo were included. Meta\u2010analysis was performed to obtain the weighted mean difference (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>), together with the corresponding 95% confidence intervals. Thirteen articles were included in the meta\u2010analysis. The <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> of probing pocket depth reduction was 0.25 mm (<jats:italic>p<\/jats:italic> &lt; 0.05) for <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> vs. Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> in single\u2010rooted teeth with moderate pockets, and clinical attachment level gain in single\u2010 and multirooted teeth with moderate pockets was 0.33 mm (<jats:italic>p<\/jats:italic> &lt; 0.05) for <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> vs. Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. Except for those, no statistically significant differences were found in the other subanalyses of <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> vs. Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FMS<\/jats:styled-content> vs. Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>. Therefore, the meta\u2010analysis results showed that <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> was better than Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> for achieving probing pocket depth reduction and clinical attachment level gain in moderate pockets. Additionally, regardless of the treatment, no serious complications were observed. <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FMS<\/jats:styled-content> and Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> are all effective for the treatment of adult chronic periodontitis, and they do not lead to any obvious discomfort among patients. Moreover, <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> had modest additional clinical benefits over Q\u2010<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>, so we prefer to recommend <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> as the first choice for the treatment of adult chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12326","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T12:21:37Z","timestamp":1445257297000},"page":"417-430","source":"Crossref","is-referenced-by-count":37,"title":["Comparison of full\u2010mouth disinfection and quadrant\u2010wise scaling in the treatment of adult chronic periodontitis: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"51","author":[{"given":"H.","family":"Fang","sequence":"first","affiliation":[{"name":"College &amp; Hospital of Stomatology Key Lab. of Oral Diseases Research of Anhui Province Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Han","sequence":"additional","affiliation":[{"name":"College &amp; Hospital of Stomatology Key Lab. of Oral Diseases Research of Anhui Province Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.\u2010L.","family":"Li","sequence":"additional","affiliation":[{"name":"College &amp; Hospital of Stomatology Key Lab. of Oral Diseases Research of Anhui Province Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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