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The metabolic profile of saliva can provide an early outlook of the changes associated with a wide range of diseases, including oral cancer and periodontal diseases. It is possible to measure levels of disease\u2010specific metabolites using different methods as presented in this study. However, many challenges exist including incomplete understanding of the complicated metabolic pathways of different oral diseases. The review concludes with the discussion on future perspectives of salivary metabolomics from a clinician point of view. Salivary metabolomics may afford a new research avenue to identify local and systemic disorders but also to aid in the design and modification of therapies. A\n                    <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                    search using keywords \u201csalivary metabolomics\u201d returned 23 results in total, of which seven were omitted for being reviews or letters to the editor. The rest of the articles were used for preparation of the review, 13 of these were published in the last 5\u00a0years.\n                  <\/jats:p>","DOI":"10.1111\/jre.12327","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T02:42:43Z","timestamp":1444272163000},"page":"431-437","source":"Crossref","is-referenced-by-count":97,"title":["Salivary metabolomics in the diagnosis of oral cancer and periodontal diseases"],"prefix":"10.1111","volume":"51","author":[{"given":"J. J. W.","family":"Mikkonen","sequence":"first","affiliation":[{"name":"SIB Labs University of Eastern Finland Kuopio Campus Kuopio Finland"},{"name":"Institute of Dentistry University of Eastern Finland Kuopio Campus Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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