{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:49:47Z","timestamp":1784022587248,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:00:00Z","timestamp":1446854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Several clinical trials describe the effectiveness of xenogeneic collagen matrix (<jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>) as an alternative option to surgical mucogingival procedures for the treatment of marginal tissue recession and augmentation of insufficient zones of keratinized tissue (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>). The aim of this systematic review and meta\u2010analysis was to evaluate the clinical and patient\u2010centred outcomes of <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> compared to other mucogingival procedures. Applying guidelines of the Preferred Reporting Items for Systematic Reviews and Meta analyses statement, randomized controlled trials were searched for in electronic databases and complemented by hand searching. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool and data were analysed using statistical software. A total of 645 studies were identified, of which, six trials were included with 487 mucogingival defects in 170 participants. Overall meta\u2010analysis showed that connective tissue graft (<jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content>) in conjunction with the coronally advanced flap (<jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>) had a significantly higher percentage of complete\/mean root coverage and mean recession reduction than <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>. Insufficient evidence was found to determine any significant differences in width of <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> had a significantly higher mean root coverage, recession reduction and gain in <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> alone. No significant differences in patient's aesthetic satisfaction were found between <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content>, except for postoperative morbidity in favour of <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>. Operating time was significantly reduced with the use of <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> but not with <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> alone. There is no evidence to demonstrate the effectiveness of <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> in achieving greater root coverage, recession reduction and gain in <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>. Superior short\u2010term results in treating root coverage compared with <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> alone are possible. There is limited evidence that <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> may improve aesthetic satisfaction, reduce postoperative morbidity and shorten the operating time. Further long\u2010term <jats:styled-content style=\"fixed-case\">randomized controlled trial<\/jats:styled-content>s are required to endorse the supposed advantages of <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12333","type":"journal-article","created":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T19:43:54Z","timestamp":1447011834000},"page":"438-452","source":"Crossref","is-referenced-by-count":45,"title":["Xenogeneic collagen matrix for periodontal plastic surgery procedures: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"51","author":[{"given":"M. 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