{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:34:52Z","timestamp":1780569292281,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007613","name":"Ankara Universitesi","doi-asserted-by":"publisher","award":["08B3334005"],"award-info":[{"award-number":["08B3334005"]}],"id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the effects of non\u2010surgical periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinase\u20108 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108), interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) and prostaglandin E<jats:sub>2<\/jats:sub> (<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub>) in patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) with periodontal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010seven patients with gingivitis and periodontitis with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, 26 patients with gingivitis and periodontitis that were systemically healthy and 13 periodontally and systemically healthy volunteers (control group) were included in this study. <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> activity was assessed by disease activity score test. The clinical periodontal parameters, fasting venous blood and gingival crevicular fluid samples were obtained and gingival crevicular fluid <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> levels were evaluated at baseline and at 3\u00a0mo follow\u2010up after non\u2010surgical periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gingival crevicular fluid <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 levels were higher in all groups than the control group. Following periodontal therapy, there were significant decreases in gingival crevicular fluid <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 levels from patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> with periodontitis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Plaque index, gingival index and bleeding on probing were significantly correlated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> at baseline and at 3\u00a0mo follow\u2010up after non\u2010surgical periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010surgical periodontal therapy of patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> with periodontitis may provide beneficial effects on local inflammatory control via decreases in gingival crevicular fluid <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12337","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T12:17:02Z","timestamp":1447762622000},"page":"586-595","source":"Crossref","is-referenced-by-count":50,"title":["The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase\u20108, interleukin\u20106 and prostaglandin E<sub>2<\/sub> levels in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"51","author":[{"given":"\u015e.","family":"Kurgan","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6.","family":"Fento\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"\u00d6nder","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Serdar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry School of Medicine Ac\u0131badem University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Ankara Numune Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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