{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:29:08Z","timestamp":1776331748649,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006002","name":"B\u00fclent Ecevit \u00dcniversitesi","doi-asserted-by":"publisher","award":["2013\u201062550515\u201002"],"award-info":[{"award-number":["2013\u201062550515\u201002"]}],"id":[{"id":"10.13039\/501100006002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background and objective<\/jats:title><jats:p>The purpose of this study was to investigate the effects of obesity on reduced and oxidized glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>) levels in the gingival crevicular fluid, plasma and saliva of patients with chronic periodontitis and to evaluate the changes after nonsurgical periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study included 60 patients: 30 patients with <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> (15 obese patients and 15 normal weight patients) and 30 healthy control subjects (15 obese patients and 15 normal weight patients). <jats:styled-content style=\"fixed-case\">Gingival crevicular fluid<\/jats:styled-content>, plasma and saliva samples were collected, and clinical periodontal measurements were recorded at baseline and at the first month after periodontal therapy from patients with <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content> levels were analyzed with spectrophotometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> levels in the plasma, saliva and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> in obese individuals with <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> were lower than in normal weight individuals at baseline (<jats:italic>p<\/jats:italic> &lt; 0.01). There was a significant difference in the <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content> ratio in plasma and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> between the obese and normal weight groups at baseline (<jats:italic>p<\/jats:italic> &lt; 0.01). The <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> levels in plasma, <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> and saliva were significantly increased in both <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> groups after nonsurgical periodontal therapy (<jats:italic>p<\/jats:italic> &lt; 0.01). A significant positive correlation was found between <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> levels in saliva, plasma and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> in all groups (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study revealed that obesity in patients with chronic periodontitis is associated with decreased <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> levels and the <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content> ratio. Moreover, nonsurgical periodontal therapy may be helpful for improvement in glutathione values in obese and normal weight individuals with chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12349","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T12:23:33Z","timestamp":1452169413000},"page":"726-734","source":"Crossref","is-referenced-by-count":23,"title":["Glutathione levels in plasma, saliva and gingival crevicular fluid after periodontal therapy in obese and normal weight individuals"],"prefix":"10.1111","volume":"51","author":[{"given":"F.","family":"\u00d6ng\u00f6z Dede","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e.","family":"Bozkurt Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Balli","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Ondokuzmayis University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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