{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:19:45Z","timestamp":1787678385641,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T00:00:00Z","timestamp":1453248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japanese Society of Periodontology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this multicenter study was to monitor disease progression in patients with chronic periodontitis during a 24\u2010mo follow\u2010up program and to evaluate the amount of bacteria in saliva and corresponding IgG titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 163 patients with chronic periodontitis who received trimonthly follow\u2010up care were observed for 24 mo. The clinical parameters and salivary content of <jats:italic>Porphyromonas gingivalis<\/jats:italic>,<jats:italic> Prevotella intermedia<\/jats:italic> and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> were assessed using the modified Invader <jats:styled-content style=\"fixed-case\">PLUS<\/jats:styled-content> assay, and the corresponding serum IgG titers were measured using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. The changes through 24 mo were analyzed using cut\u2010off values calculated for each factor. One\u2010way <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> or Fisher's exact test was used to perform between\u2010group comparison for the data collected. Diagnostic values were calculated using Fisher's exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 124 individuals who completed the 24\u2010mo monitoring phase, 62 exhibited periodontitis progression, whereas 62 demonstrated stable disease. Seven patients withdrew because of acute periodontal abscess. The ratio of <jats:italic>P. gingivalis<\/jats:italic> to total bacteria and the combination of <jats:italic>P. gingivalis<\/jats:italic> counts and IgG titers against <jats:italic>P. gingivalis<\/jats:italic> were significantly related to the progression of periodontitis. The combination of <jats:italic>P. gingivalis<\/jats:italic> ratio and <jats:italic>P. gingivalis<\/jats:italic> IgG titers was significantly associated with the progression of periodontitis (<jats:italic>p<\/jats:italic> = 0.001, sensitivity = 0.339, specificity = 0.790).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is suggested that the combination of <jats:italic>P. gingivalis<\/jats:italic> ratio in saliva and serum IgG titers against <jats:italic>P. gingivalis<\/jats:italic> may be associated with the progression of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12353","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T05:05:05Z","timestamp":1453352705000},"page":"768-778","source":"Crossref","is-referenced-by-count":31,"title":["Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24\u2010mo prospective multicenter cohort study"],"prefix":"10.1111","volume":"51","author":[{"given":"T.","family":"Morozumi","sequence":"first","affiliation":[{"name":"Division of Periodontology Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Surgery School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Translational Research Tsurumi University School of Dental Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Endodontology Department of Oral Health Science Hokkaido University Graduate School of Dental Medicine 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