{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:47:24Z","timestamp":1793227644705,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["01121056"],"award-info":[{"award-number":["01121056"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Although low\u2010level laser therapy (<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>) has been demonstrated to have a biomodulatory effect on periodontal tissue, no systematic review has exclusively addressed its effectiveness as an adjunct to non\u2010surgical periodontal treatment. This study aimed to evaluate whether an additional benefit exists for the application of <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> compared with scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>An extensive search was conducted in the Cochrane Library (Issue 8, 2015), PubMed (1997) and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> (1947) before August 2015 for randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s). The bias risk was assessed with the Cochrane tool for risk of bias evaluation. A meta\u2010analysis was performed using <jats:styled-content style=\"fixed-case\">REVMAN<\/jats:styled-content> 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After independent screening of 354 initial records, eight publications (seven <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) were included. However, six were rated as \u2018having a high risk of bias\u2019 as a result of major methodological weakness in \u2018allocation concealment\u2019 and \u2018blinding of key personnel\u2019. Meta\u2010analysis showed that <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>\u2010mediated <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> demonstrated significant short\u2010term benefits over <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> monotherapy in the improvement of the probing pocket depth (<jats:italic>p<\/jats:italic> = 0.0009 at 1 mo; <jats:italic>p<\/jats:italic> = 0.03 at 2 mo) and the level of interleukin\u20101\u03b2 in the gingival crevicular fluid (<jats:italic>p<\/jats:italic> = 0.01 at 1 mo). Nevertheless, <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> failed to show significant additional intermediate\u2010term (3 and 6 mo) effects in terms of clinical parameters and alveolar bone density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings indicated that <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> showed only short\u2010term additional benefits after conventional <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. Its long\u2010term effects remain unclear due to substantial methodological weaknesses and an insufficient number of current studies. Future <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s with better designs and longer follow\u2010up periods are required to assess the effectiveness of <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> as an adjunctive treatment strategy in patients with periodontal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12361","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T05:31:27Z","timestamp":1456896687000},"page":"8-20","source":"Crossref","is-referenced-by-count":81,"title":["The effectiveness of low\u2010level laser therapy as an adjunct to non\u2010surgical periodontal treatment: a meta\u2010analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"C.","family":"Ren","sequence":"first","affiliation":[{"name":"Faculty of Dentistry the University of Hong Kong Hong Kong SAR 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