{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:42:46Z","timestamp":1779118966997,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colgate Palmolive Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Triclosan\/copolymer toothpaste is effective in controlling plaque and gingivitis and in slowing the progression of periodontitis. This study describes its influence on microbiological and clinical outcomes, over a 5\u2010year period, in patients with established cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Four\u2010hundred and thirty\u2010eight patients were recruited from the Cardiovascular Unit at The Prince Charles Hospital, Brisbane, Australia, and randomized to triclosan or placebo groups. Six sites per tooth were examined annually for probing pocket depth and loss of attachment. These outcomes were analysed, using generalized linear modelling, in 381 patients who had measurements from consecutive examinations. Concurrent load of the periodontal pathogens <jats:italic>Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Tannerella forsythia<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic> was determined, using quantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, in 437 patients with baseline plaque samples. Group comparisons were expressed as geometric means. The chi\u2010square test was used to test for differences between the two groups of patients with regard to the proportion of patients with different numbers of bacterial species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in general health or periodontal status between the groups at baseline. There was a significant reduction in the number of interproximal sites showing loss of attachment between examinations, by 21% on average (<jats:italic>p<\/jats:italic> &lt; 0.01), in the triclosan group compared with the placebo group. The prevalence of patients with <jats:italic>F. nucleatum<\/jats:italic> and <jats:italic>A. actinomycetemcomitans<\/jats:italic> was high and remained relatively constant throughout the 5 years of the study. In contrast, the prevalence of <jats:italic>T. forsythia<\/jats:italic> and <jats:italic>P. gingivalis<\/jats:italic> showed more variability; however, there was no significant difference between the groups, at any time point, in the prevalence of any organism. A significant difference in the geometric means for <jats:italic>P. gingivalis<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.01) was seen at years 1 and 4, and for <jats:italic>F. nucleatum<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.01) and in the total bacterial load (<jats:italic>p<\/jats:italic> = 0.03) at year 2; however, these differences were not statistically significant following a Bonferroni correction for multiple comparisons. There was no difference between the groups in the geometric means for each organism at year 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of the study, these data suggest that the use of triclosan\/copolymer toothpaste significantly slowed the progression of periodontitis in patients with <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> but that it had little influence on key subgingival periodontopathic bacteria in these patients over the 5 years of the study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12369","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T05:54:46Z","timestamp":1456898086000},"page":"61-73","source":"Crossref","is-referenced-by-count":14,"title":["Influence of a triclosan toothpaste on periodontopathic bacteria and periodontitis progression in cardiovascular patients: a randomized controlled trial"],"prefix":"10.1111","volume":"52","author":[{"given":"G. J.","family":"Seymour","sequence":"first","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Qld Australia"},{"name":"The Sir John Walsh Research Institute University of Otago Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Palmer","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Leishman","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Qld Australia"},{"name":"School of Dentistry The University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. L.","family":"Do","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Westerman","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Carle","sequence":"additional","affiliation":[{"name":"Metro North Hospital and Health Service The Prince Charles Hospital Chermside Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Faddy","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences Queensland University of Technology Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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