{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:43:12Z","timestamp":1788788592764,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Background and Objective<\/jats:title>Periodontal disease has been described as playing a role in the atherosclerosis process, and its relation with intimal thickness and vascular endothelial function (EF) has been investigated. The present study sought to determine whether there are differences in parameters of arterial stiffness and EF between patients with and without severe periodontal disease (SPD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Patients referred to the School of Dentistry University of Buenos Aires, were assessed. Demographic characteristics, atherogenic risk factors and concomitant pathologies were recorded. Patients with known cardiovascular pathology were excluded. Using carotid Doppler ultrasound an operator assessed arterial stiffness parameters: compliance, elastic modulus (EM<\/jats:styled-content>), \u03b2 stiffness index (\u03b2SI<\/jats:styled-content>) and vascular EF<\/jats:styled-content> by brachial artery flow\u2010mediated dilatation. The patients were divided into two groups: with and without SPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty patients were included; 60% were women; 15 were in the SPD<\/jats:styled-content> group and 25 in the group without SPD<\/jats:styled-content>. Respective results of the studied variables were: age 56.53 \u00b1 17.58 vs. 51.12 \u00b1 12.97 years (NS<\/jats:styled-content>); probing depth 2.53 \u00b1 1.30 (95% CI<\/jats:styled-content> 1.81\u20133.25) vs. 1.25 \u00b1 0.51 (95% CI<\/jats:styled-content> 1.31\u20131.73) p<\/jats:italic> = 0.02; clinical attachment level 4.80 \u00b1 2.00 (95% CI<\/jats:styled-content> 3.69\u20135.91) vs. 1.72 \u00b1 0.93 (95% CI<\/jats:styled-content> 1.33\u20132.11) p<\/jats:italic> = 0.001; intimal thickness 0.10 \u00b1 0.17 (95% CI<\/jats:styled-content> 0.095\u20130.11) vs. 0.82 \u00b1 0.18 (95% CI<\/jats:styled-content> 0.074\u20130.98) (NS<\/jats:styled-content>); EM<\/jats:styled-content> 48.33 \u00b1 12.53 vs. 38.86 \u00b1 7.69 (p<\/jats:italic> = 0.005); \u03b2SI<\/jats:styled-content> 4.21 \u00b1 1.03 vs. 3.64 \u00b1 1.02 (p<\/jats:italic> = 0.004); EF<\/jats:styled-content> 16.13 \u00b1 5.02 vs. 22.76 \u00b1 4.50 (p<\/jats:italic> = 0.0003). Correlation between: EM<\/jats:styled-content> and clinical attachment level <\/jats:styled-content>r<\/jats:italic> = 0.58 (p<\/jats:italic> < 0.001), \u03b2SI<\/jats:styled-content> and clinical attachment level <\/jats:styled-content>r<\/jats:italic> = 0.66 (p<\/jats:italic> < 0.001), EF<\/jats:styled-content> and clinical attachment level<\/jats:styled-content> 0.59 (p<\/jats:italic> < 0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Parameters of arterial stiffness and EF were worse in patients with SPD and correlated moderately with clinical attachment level. Correlation with compliance and EF was negative.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12376","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T05:56:47Z","timestamp":1459144607000},"page":"122-126","source":"Crossref","is-referenced-by-count":14,"title":["Relation between periodontal disease and arterial stiffness"],"prefix":"10.1111","volume":"52","author":[{"given":"L. N.","family":"Nicolosi","sequence":"first","affiliation":[{"name":"Department of Cardiology Spanish Hospital of Buenos Aires Buenos Aires Argentina"},{"name":"Department of Buccodental and Clinical Pathology Cardiovascular Physiopathology Institute, School of Dentistry, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. G.","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Buccodental and Clinical Pathology Cardiovascular Physiopathology Institute, School of Dentistry, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Rudzinski","sequence":"additional","affiliation":[{"name":"Department of Buccodental and Clinical Pathology Cardiovascular Physiopathology Institute, School of Dentistry, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pompeo","sequence":"additional","affiliation":[{"name":"Department of Buccodental and Clinical Pathology Cardiovascular Physiopathology Institute, School of Dentistry, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Guanca","sequence":"additional","affiliation":[{"name":"Department of Buccodental and Clinical Pathology Cardiovascular Physiopathology Institute, School of Dentistry, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Buccodental and Clinical Pathology Cardiovascular Physiopathology Institute, School of Dentistry, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Gelpi","sequence":"additional","affiliation":[{"name":"Department of Pathology Cardiovascular Physiopathology Institute, School of Medicine, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Rubio","sequence":"additional","affiliation":[{"name":"Department of Cardiology Spanish Hospital of Buenos Aires Buenos Aires Argentina"},{"name":"Department of Buccodental and Clinical Pathology Cardiovascular Physiopathology Institute, School of Dentistry, University of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31825719f3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/768237"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.249680"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114688"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.6.2510"},{"issue":"5","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1161\/01.CIR.88.5.2149","article-title":"Cigarette smoking is associated with dose\u2010related and potentially reversible impairment of endothelium\u2010dependent dilation in healthy young adults","volume":"88","author":"Celermajer DS","year":"1993","journal-title":"Circulation"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1094"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.16.1899"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.074"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.08.013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041747"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.097803"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078603.90302.4A"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1221"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101535"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.660"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.38"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.059"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.10.002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1694"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.04.002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.3.485"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2007.22.3.147"},{"key":"e_1_2_6_28_1","first-page":"11","article-title":"Methodological aspects of epidemiological studies of periodontal diseases","volume":"2002","author":"Kingman A","year":"2000","journal-title":"Periodontol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal disease and conditions","volume":"4","author":"Amitage GC","year":"1999","journal-title":"Ann Periodontol"},{"key":"e_1_2_6_30_1","first-page":"1253","article-title":"Carotid artery stiffness as an early marker of vascular lesions in children and adolescents with cardiovascular risk factor","volume":"63","author":"Nu\u00f1ez F","year":"2010","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097034"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000136767.71518.36"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319707306299"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1258\/cvd.2012.012016"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.10.018"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3280119012"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652859"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.017"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103449"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.12.003"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12376","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:20:27Z","timestamp":1696148427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/jre.12376"],"URL":"https:\/\/doi.org\/10.1111\/jre.12376","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}