{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:34:45Z","timestamp":1789382085556,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102015R1A2A2A01004589"],"award-info":[{"award-number":["NRF\u20102015R1A2A2A01004589"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"\n Background and Objective<\/jats:title>\n \n Periodontal ligament stem cells (\n PDLSC<\/jats:styled-content>\n s) from the periodontal ligament tissue were recently identified as mesenchymal stem cells (\n MSC<\/jats:styled-content>\n s). The capabilities of\n PDLSC<\/jats:styled-content>\n s in periodontal tissue or bone regeneration have been reported, but their immunomodulatory role in T\u2010cell immune responses via dendritic cells (\n DC<\/jats:styled-content>\n s), known as the most potent antigen\u2010presenting cell, has not been studied. The aim of this study is to understand the immunological function of homogeneous human\n STRO<\/jats:styled-content>\n \u20101\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 146\n +<\/jats:sup>\n PDLSC<\/jats:styled-content>\n s in\n DC<\/jats:styled-content>\n \u2010mediated T\u2010cell immune responses to modulate the periodontal disease process.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n We utilized highly purified (>\u00a095%) human\n STRO<\/jats:styled-content>\n \u20101\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 146\n +<\/jats:sup>\n PDLSC<\/jats:styled-content>\n s and human bone marrow mesenchymal stem cells (\n BMSC<\/jats:styled-content>\n s). Each stem cell was co\u2010cultured with human monocyte\u2010derived\n DC<\/jats:styled-content>\n s in the presence of lipopolysaccharide isolated from\n Porphyromonas gingivalis<\/jats:italic>\n , a major pathogenic bacterium responsible for periodontal disease,\n in\u00a0vitro<\/jats:italic>\n to examine the immunological effect of each stem cell on\n DC<\/jats:styled-content>\n s and\n DC<\/jats:styled-content>\n \u2010mediated T\u2010cell proliferation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We discovered that\n STRO<\/jats:styled-content>\n \u20101\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 146\n +<\/jats:sup>\n PDLSC<\/jats:styled-content>\n s, as well as\n BMSC<\/jats:styled-content>\n s, significantly decreased the level of non\u2010classical major histocompatibility complex glycoprotein\n CD<\/jats:styled-content>\n 1b on\n DC<\/jats:styled-content>\n s, resulting in defective T\u2010cell proliferation, whereas most human leukocyte antigens and the co\u2010stimulatory molecules\n CD<\/jats:styled-content>\n 80 and\n CD<\/jats:styled-content>\n 86 in\/on\n DC<\/jats:styled-content>\n s were not significantly affected by the presence of\n BMSC<\/jats:styled-content>\n s or\n STRO<\/jats:styled-content>\n \u20101\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 146\n +<\/jats:sup>\n PDLSC<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study unveiled an immunomodulatory role of\n STRO<\/jats:styled-content>\n \u20101\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 146\n +<\/jats:sup>\n PDLSC<\/jats:styled-content>\n s in negatively regulating\n DC<\/jats:styled-content>\n \u2010mediated T\u2010cell immune responses, demonstrating their potential to be utilized in promising new stem cell therapies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jre.12378","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T21:47:54Z","timestamp":1459288074000},"page":"135-146","source":"Crossref","is-referenced-by-count":45,"title":["Human periodontal ligament stem cells suppress T\u2010cell proliferation via down\u2010regulation of non\u2010classical major histocompatibility complex\u2010like glycoprotein\n CD<\/scp>\n 1b on dendritic cells"],"prefix":"10.1111","volume":"52","author":[{"given":"C.","family":"Shin","sequence":"first","affiliation":[{"name":"School of Life Sciences Ulsan National Institute of Science and Technology Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology Pohang 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