{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:28:21Z","timestamp":1787243301341,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Background and Objective<\/jats:title>\n \n In the therapy of destructive periodontal disease, chemical antimicrobial agents and increasingly photodynamic therapy (\n PDT<\/jats:styled-content>\n ) play an important adjunctive role to standard mechanical anti\u2010infective treatment procedures. However, both antiseptic methods have their shortcomings in terms of eliminating periodontal pathogens. The aim of the study was to compare the antibacterial efficacy of different antiseptic mouthrinses, of a conventional and a new, modified\n PDT<\/jats:styled-content>\n plus<\/jats:sup>\n as well as of the different antiseptic mouthrinses combined with either the conventional or the modified\n PDT<\/jats:styled-content>\n plus<\/jats:sup>\n against periopathogens.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n Six representative periodontitis\u2010associated bacterial strains were grown for 24 h under anaerobic conditions. After mixing the individual cell pellets they were exposed to 10 different antiseptic mouthrinse formulations: chlorhexidine (0.2%, 0.06%,\n CHX<\/jats:styled-content>\n );\n CHX<\/jats:styled-content>\n + cetylpyridinium chloride (each 0.05%); sodium hypochlorite (0.05%); polyhexanide (0.04%,\n PHMB<\/jats:styled-content>\n 1; 0.1%,\n PHMB<\/jats:styled-content>\n 2); octenidine dihydrochloride (0.1%); fluoride (250 ppm); essential oils; povidone iodine (10%); and saline (0.9%, NaCl) as control. Furthermore, the bacteria were treated with conventional\n PDT<\/jats:styled-content>\n based on light\u2010emitting diodes and a new modified photodisinfection combining photosensitizer with hydrogen peroxide to\n PDT<\/jats:styled-content>\n plus<\/jats:sup>\n also based on light\u2010emitting diodes. In addition to the single treatments, a combined application of antiseptic exposure followed by use of\n PDT<\/jats:styled-content>\n or\n PDT<\/jats:styled-content>\n plus<\/jats:sup>\n was performed. The microbial viability was characterized by analyzing colony growth and fluorescence\u2010based vitality proportions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Nearly all mouthrinses caused a statistically significant growth inhibition. The most effective antiseptics,\n CHX<\/jats:styled-content>\n (0.2%),\n CHX<\/jats:styled-content>\n \/cetylpyridinium chloride and octenidine dihydrochloride, inhibited bacterial growth completely. Conventional\n PDT<\/jats:styled-content>\n resulted in moderate reduction of colony growth. The modified\n PDT<\/jats:styled-content>\n plus<\/jats:sup>\n achieved maximum antimicrobial effect. The combination of antiseptic exposure and\n PDT<\/jats:styled-content>\n against periopathogens predominantly increased antibacterial efficacy compared to the single applications. The mouthrinse containing essential oil seemed to interfere with\n PDT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A combination therapy of preceding chemotherapeutical exposure and subsequent photodisinfection may be a more effective and promising antibacterial treatment than single applications of the antiseptic methods. The modified\n PDT<\/jats:styled-content>\n plus<\/jats:sup>\n using oxygen\u2010enriched toluidine showed a superior antibacterial effect on periodontal pathogens to conventional\n PDT<\/jats:styled-content>\n and to the majority of the investigated mouthrinses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jre.12379","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T13:28:31Z","timestamp":1459603711000},"page":"162-175","source":"Crossref","is-referenced-by-count":32,"title":["Antimicrobial efficiency of mouthrinses versus and in combination with different photodynamic therapies on periodontal pathogens in an experimental study"],"prefix":"10.1111","volume":"52","author":[{"given":"E.\u2010M.","family":"Decker","sequence":"first","affiliation":[{"name":"Department for Pediatric and Operative Dentistry Periodontology and Endodontology University of T\u00fcbingen Center of Dentistry, Oral Medicine and Maxillofacial Surgery Tuebingen 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