{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:32:14Z","timestamp":1790688734503,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Counsil of Technological and Scientific Development - (CNPQ - Bras\u00edlia, Distrito Federal, Brazil)","award":["303868\/2013-9"],"award-info":[{"award-number":["303868\/2013-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Periodontitis is a chronic inflammatory disease of periodontal tissues that leads to the destruction of bone and other connective tissues. Resveratrol and curcumin are plant\u2010derived substances with biological properties that may have immunomodulatory properties. This study investigated the effect of continuous administration of resveratrol and curcumin and the association of resveratrol and curcumin on the progression of experimental periodontitis in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Forty Wistar rats were assigned randomly to the following groups: group 1, experimental periodontitis + placebo (<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>= 10); group 2, experimental periodontitis + resveratrol (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>= 10); group 3, experimental periodontitis + curcumin (C) (<jats:italic>n<\/jats:italic>= 10); and group 4, experimental periodontitis + resveratrol + curcumin (<jats:styled-content style=\"fixed-case\">COMBI<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>= 10). Periodontitis was induced in rats by tying a silk suture, as a ligature, around one of the first molars. Daily administration of the placebo solution, 10 mg\/kg of resveratrol, 100 mg\/kg of curcumin or 10 mg\/kg of resveratrol plus 100 mg\/kg of curcumin was carried out from day 0 to day 30. At the end of the relevant experimental periods, rats were killed and the specimens obtained were processed for morphometric analysis of bone loss. Gingival tissues surrounding the first molar were collected for quantification of interleukin (<jats:styled-content style=\"fixed-case\">IL)<\/jats:styled-content>\u20101\u03b2,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, interferon\u2010gamma (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3) and tumor necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) using a Luminex\/<jats:styled-content style=\"fixed-case\">MAG<\/jats:styled-content>PIX assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intergroup comparisons of the morphometric outcomes revealed higher bone\u2010loss values in the<jats:styled-content style=\"fixed-case\">PL group<\/jats:styled-content>(<jats:italic>p<\/jats:italic>&lt; 0.05) when compared with<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>, C and<jats:styled-content style=\"fixed-case\">COMBI groups<\/jats:styled-content>. There was no difference in bone\u2010loss values among<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>, C and<jats:styled-content style=\"fixed-case\">COMBI<\/jats:styled-content>groups (<jats:italic>p<\/jats:italic>&gt; 0.05). The immunoenzymatic assay of the gingival tissue showed a lower concentration of<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 in the<jats:styled-content style=\"fixed-case\">COMBI<\/jats:styled-content>group in comparison with the<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>group (<jats:italic>p<\/jats:italic>&lt; 0.05). Higher values of<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 were demonstrated in groups<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>, C and<jats:styled-content style=\"fixed-case\">COMBI<\/jats:styled-content>in comparison with the<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>group (<jats:italic>p<\/jats:italic>&lt; 0.05). Only<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>caused a reduction in the levels of<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 (<jats:italic>p<\/jats:italic>&lt; 0.05). There was no difference in the concentration of<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 amongst the four groups (<jats:italic>p<\/jats:italic>&gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Resveratrol and curcumin are capable of reducing alveolar bone loss in an animal model of periodontitis. This occurred when these agents were added singly or in combination with one another, but there did not appear to be either synergistic or additive effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12382","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T16:52:32Z","timestamp":1462207952000},"page":"201-209","source":"Crossref","is-referenced-by-count":96,"title":["Systemic treatment with resveratrol and\/or curcumin reduces the progression of experimental periodontitis in rats"],"prefix":"10.1111","volume":"52","author":[{"given":"M. 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