{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:38:14Z","timestamp":1769344694091,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T00:00:00Z","timestamp":1460764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The balance between host proinflammatory and anti\u2010inflammatory immune responses is a key determinant for the pathogenesis of periodontal disease. This study aimed to explore the possibility of an association between lipoxin A4 and interleukin\u201012 in chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Forty\u2010five patients with chronic periodontitis and 45 periodontally healthy patients were included in this case\u2013control study. Plaque index, calculus index, gingival index, sulcus bleeding index, full\u2010mouth probing depth and clinical attachment loss were recorded. <jats:styled-content style=\"fixed-case\">Gingival crevicular fluid<\/jats:styled-content> samples were collected and analysed for interleukin\u201012 and lipoxin A4 using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean concentration of lipoxin A4 was lower in the periodontitis group compared with the periodontally healthy group. There was a negative correlation between interleukin\u201012 and lipoxin A4 in both groups. There was a negative correlation between clinical attachment loss and lipoxin A4, and a positive correlation between clinical attachment loss and interleukin\u201012. However, the correlations were statistically insignificant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The mean interleukin\u201012 concentration was significantly higher in gingival crevicular fluid from patients with periodontitis than in that from with healthy patients, and the mean lipoxin A4 concentration was lower in patients with periodontitis than in healthy patients. Lipoxin A4 possibly has an inhibitory effect on interleukin\u201012.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12383","type":"journal-article","created":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T09:12:30Z","timestamp":1460797950000},"page":"210-217","source":"Crossref","is-referenced-by-count":9,"title":["Association between lipoxin A4 and interleukin\u201012 in gingival crevicular fluid: a preliminary investigation"],"prefix":"10.1111","volume":"52","author":[{"given":"F.","family":"Tarannum","sequence":"first","affiliation":[{"name":"Department of Periodontics M.R. Ambedkar Dental College and Hospital Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Faizuddin","sequence":"additional","affiliation":[{"name":"Department of Periodontics M.R. Ambedkar Dental College and Hospital Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060465"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141647"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2168"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.12.4132"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6856"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi992551b"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00043-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.265"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021183"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205738200"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01322.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.602"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_7_17_1","first-page":"107","article-title":"Gingival sulcus bleeding index \u2013 a leading symptom in initial gingivitis","volume":"15","author":"Muhlemann HR","year":"1971","journal-title":"Helv Odontol Acta"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2779"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201202382"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200202"},{"key":"e_1_2_7_21_1","first-page":"111","article-title":"Evaluation of interleukin 8, 12 & 33 serum level in patients with chronic periodontitis, aggressive periodontitis and healthy subjects","volume":"9","author":"Ladez MA","year":"2012","journal-title":"Life Sci J"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin\u201012 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trincheri G","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2006.00292.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03110.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060331"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-10-57"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.8.1237"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12383","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:26:20Z","timestamp":1696281980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,16]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jre.12383"],"URL":"https:\/\/doi.org\/10.1111\/jre.12383","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,16]]}}}