{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:58:12Z","timestamp":1791212292733,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) is a powerful stimulator of osteoclast differentiation and bone resorption. Production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 is modulated by polymorphisms, and higher levels of this cytokine are found locally in patients with chronic periodontitis. In this study we performed a modern approach \u2013 Complete physical mapping of the <jats:italic>IL6<\/jats:italic> gene \u2013 to identify the polymorphisms associated with chronic periodontitis in a southern Brazilian population sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>One\u2010hundred and nine individuals of both genders (mean age: 41.5 \u00b1 8.5 years) were divided into a study group (56 participants with periodontitis) and a control group (53 individuals without periodontitis). After collection and purification of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, nine tag single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s; rs1524107, rs2069835, rs2069837, rs2069838, rs2069840, rs2069842, rs2069843, rs2069845 and rs2069849) covering the entire gene were selected according to the information available on the International HapMap Project website and evaluated using real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differences in the distribution of the following parameters were statistically significant between study and control groups: number of teeth (<jats:italic>p<\/jats:italic> = 0.030); probing depth (<jats:italic>p<\/jats:italic> &lt; 0.001); clinical attachment level (<jats:italic>p<\/jats:italic> &lt; 0.001); gingival index (<jats:italic>p<\/jats:italic> &lt; 0.001); plaque index (<jats:italic>p<\/jats:italic> = 0.003); calculus index (<jats:italic>p<\/jats:italic> &lt; 0.001); and dental mobility (<jats:italic>p<\/jats:italic> &lt; 0.001). It was found that marker rs2069837 (located in intron 2 of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<\/jats:italic>) under G dominant was associated with protection against chronic periodontitis in a Brazilian population in the presence of clinical variables, such as visible plaque, dentist visit frequency and dental floss use, and was suggested for the first time as a marker of susceptibility to chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Complete physical mapping of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<\/jats:italic> (using tag <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) was carried out for the first time, unveiling allele G of polymorphism rs2069837 (located in the second intron of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<\/jats:italic>) as a suggestive marker of protection against chronic periodontitis in a Brazilian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12389","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T13:51:46Z","timestamp":1463147506000},"page":"255-261","source":"Crossref","is-referenced-by-count":16,"title":["Complete physical mapping of <i><scp>IL<\/scp>6<\/i> reveals a new marker associated with chronic periodontitis"],"prefix":"10.1111","volume":"52","author":[{"given":"S. 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