{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:18:14Z","timestamp":1793870294055,"version":"4.6.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006702","name":"Universidade do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>This pilot cohort study evaluated the effect of periodontal treatment on renal function, metabolic markers and asymmetric dimethylarginine (<jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content>) in patients with pre\u2010dialysis chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) presenting chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010six patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> and severe chronic periodontitis were selected. Periodontal parameters included plaque index, bleeding on probing, probing pocket depth and clinical attachment level. Estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>), triglycerides, total cholesterol, albumin and <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> levels were evaluated at baseline, 90 and 180 d after periodontal therapy. e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was evaluated by the <jats:styled-content style=\"fixed-case\">Modification of Diet in Renal Disease<\/jats:styled-content> equation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All periodontal clinical parameters significantly improved (<jats:italic>p<\/jats:italic> &lt; 0.05) 180 d after periodontal therapy. There was a significant improvement on the median values (25%; 75% percentiles) of <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> from 34.6 (27; 44.7) mL\/min\/1.73 m<jats:sup>2<\/jats:sup> on baseline to 37.6 (29.7; 57) mL\/min\/1.73 m<jats:sup>2<\/jats:sup> on day 90, and to 37.6 (28.6; 56) mL\/min\/1.73 m<jats:sup>2<\/jats:sup> (<jats:italic>p<\/jats:italic> &lt; 0.05) on day 180. <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> levels significantly reduced 180 d after periodontal treatment. No significant differences were observed at the median values of metabolic markers comparing baseline and 180 d after periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results point to a link of kidney disease with endothelium dysfunction and periodontitis, suggesting that periodontal treatment may be beneficial to the course of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12390","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T16:52:12Z","timestamp":1462207932000},"page":"262-267","source":"Crossref","is-referenced-by-count":61,"title":["Periodontal treatment in patients with chronic kidney disease: a pilot study"],"prefix":"10.1111","volume":"52","author":[{"given":"S.","family":"Almeida","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Odontology Rio de Janeiro State University Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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