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Smoking is a major risk factor for the development of numerous systemic diseases, as well as periodontitis. While it is clear that smokers have a significantly enhanced risk for developing periodontitis leading to tooth loss, the population varies regarding susceptibility to disease associated with smoking. This investigation focused on identifying differences in four broad sets of variables, consisting of: (i) host\u2010response molecules; (ii) periodontal clinical parameters; (iii) antibody responses to periodontal pathogens and oral commensal bacteria; and (iv) other variables of interest, in a population of smokers with (<jats:italic>n<\/jats:italic> = 171) and without (<jats:italic>n<\/jats:italic> = 117) periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Bayesian network structured learning (<jats:styled-content style=\"fixed-case\">BNSL<\/jats:styled-content>) techniques were used to investigate potential associations and cross\u2010talk between the four broad sets of variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BNSL<\/jats:styled-content> revealed two broad communities with markedly different topology between the populations of smokers, with and without periodontitis. Confidence of the edges in the resulting network also showed marked variations within and between the periodontitis and nonperiodontitis groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results presented validated known associations and discovered new ones with minimal precedence that may warrant further investigation and novel hypothesis generation. Cross\u2010talk between the clinical variables and antibody profiles of bacteria were especially pronounced in the case of periodontitis and were mediated by the antibody response profile to <jats:italic>Porphyromonas gingivalis<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12397","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T12:18:44Z","timestamp":1468930724000},"page":"342-352","source":"Crossref","is-referenced-by-count":13,"title":["Cross\u2010talk between clinical and host\u2010response parameters of periodontitis in smokers"],"prefix":"10.1111","volume":"52","author":[{"given":"R.","family":"Nagarajan","sequence":"first","affiliation":[{"name":"Division of Biomedical Informatics College of Medicine University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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