{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:56:52Z","timestamp":1766415412436},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The retention of suprabony connective fibres attached into the root cementum during fibre retention osseous resective surgery (FibRe<jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content>) results in a more conservative intrasurgical removal of bone, and limits further bone loss and patient morbidity during healing, compared with conventional osseous resective surgery (<jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content>). This may be a result of the protective effect of preserved connective tissue over the interproximal sites and the lower activation of the inflammatory mechanisms. Thus, the aim of this pilot study was to compare the expression of inflammatory and osteoclastic activity markers in gingival tissues following FibRe<jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content> in the early postsurgical phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010six posterior sextants requiring osseous resective surgery were selected in 13 patients with chronic periodontitis: 13 sextants were randomly assigned to <jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content> and 13 to FibRe<jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content> in a split\u2010mouth design. Gingival biospies were collected during the surgical sessions and at suture removal. Tissue samples were analysed to evaluate the expression of proinflammatory and immunity regulatory mediators (interleukin\u20101\u03b1, C\u2010X\u2010C motif chemokine ligand 5, interferon\u2010\u03b3 and tumour necrosis factor\u2010\u03b1), cluster of differentiation 14 (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14; a monocyte\/macrophage marker) and TRAP (an osteoclast marker) using immunohistochemical, immunofluorescence and cytofluorimetric analyses, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postsurgery, a higher number of inflammatory cells and stronger expression of proinflammatory cytokines were observed in the epithelium and connective tissue of <jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content> gingival samples compared with FibRe<jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content> gingival samples (<jats:italic>p<\/jats:italic> &lt; 0.001). This was accompanied by increased numbers of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14\u2010positive and <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\u2010positive cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Retention of the supracrestal connective fibres appears to reduce the postsurgical intensity of the host\u2010mediated inflammatory response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12400","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T07:29:03Z","timestamp":1468999743000},"page":"368-376","source":"Crossref","is-referenced-by-count":6,"title":["Increased early inflammatory response and osteoclastic activity in gingival tissues following conventional osseous resective surgery compared with the fibre retention technique: a pilot study"],"prefix":"10.1111","volume":"52","author":[{"given":"F.","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences C.I.R. 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