{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:13:11Z","timestamp":1792699991150,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The cytokine, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201032, is a relatively new discovery. However, it is very powerful for stimulating tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) under inflammatory conditions. The objective of this research was to explore fluctuations in the levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201032 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, in both saliva and gingival crevicular fluid. The focus was on measurements taken before and after clinical treatment of chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>For the purposes of the study, a total of 27 patients with <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> and 27 controls (periodontally healthy) were recruited. Important clinical periodontal criteria were established before and 4 wk after the start of the research. The <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> group was given an initial form of periodontal care. Samples of saliva and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> were collected exactly 4 wk preceding and 4 wk following the care. The levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201032 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 present in saliva and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> were recorded via the use of an ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, the levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201032 in the <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> and saliva were significantly higher among patients in the <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> group than among patients in the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). On the other hand, at baseline the levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 were significantly lower in the <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> and saliva of the <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> group than the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). A significantly positive link was found between the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201032 levels in the two study groups (<jats:italic>p<\/jats:italic> &lt; 0.05). After treatment, the levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201032 in saliva and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> were significantly lower in the <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> group when compared with the baseline readings. However, the levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 were significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultimately, the level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201032 present in saliva and <jats:styled-content style=\"fixed-case\">gingival crevicular fluid<\/jats:styled-content> might be useful as an indicator of the condition and the expectations for its treatment and care. According to the results of the research, the proinflammatory impact of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201032 could potentially be linked to the intensity and progression of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12404","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T20:23:50Z","timestamp":1470687830000},"page":"397-407","source":"Crossref","is-referenced-by-count":22,"title":["Interleukin\u201032 levels in gingival crevicular fluid and saliva of patients with chronic periodontitis after periodontal treatment"],"prefix":"10.1111","volume":"52","author":[{"given":"F.","family":"\u00d6ng\u00f6z Dede","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Balli","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of 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