{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:45:13Z","timestamp":1762101913945},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Mannose\u2010binding lectin (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) plays an important role in innate immunity. MBL deficiency is usually caused by mutations in exon 1 of the <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> structural gene (<jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic>). Our aim was to investigate <jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic> polymorphisms and their relation to salivary levels of periodontal inflammatory\/tissue destruction markers and two major periodontitis\u2010associated bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Salivary samples from 222 subjects were available for genotyping by pyrosequencing. The subjects between 40 and 60 years of age and having a minimum of 20 teeth were divided into three periodontal groups: 80 had generalized periodontitis, 65 had localized periodontitis and 77 were periodontitis\u2010free. A comparison between their <jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic> genotypes and salivary detection rates and levels of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic> as well as interleukin \u20101\u03b2, matrix metalloproteinase \u20108, and tissue inhibitor of matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>)\u20101 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of the <jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic> wild\u2010type (A\/A), heterozygote variants (A\/O) and homozygote variants (O\/O) were 69.4%, 26.6% and 4%, respectively. In <jats:italic>A. actinomycetemcomitans<\/jats:italic>\u2010positive subjects having homozygote or heterozygote <jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic> variants, the salivary concentrations of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 (<jats:italic>p<\/jats:italic> = 0.010) were elevated and those of <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101 (<jats:italic>p<\/jats:italic> = 0.001) were decreased. In addition their matrix metalloproteinase \u20108\/<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101 ratio was higher (<jats:italic>p<\/jats:italic> &lt; 0.001) and they had more pocket teeth (<jats:italic>p<\/jats:italic> = 0.012) than subjects negative for <jats:italic>A. actinomycetemcomitans<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that the carriage of <jats:italic>A. actinomycetemcomitans<\/jats:italic> may facilitate extended periodontal inflammation and destruction in subjects with a variant form of human <jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12420","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T05:52:44Z","timestamp":1473832364000},"page":"540-545","source":"Crossref","is-referenced-by-count":10,"title":["Mannose\u2010binding lectin gene polymorphism in relation to periodontal infection"],"prefix":"10.1111","volume":"52","author":[{"given":"A.","family":"Liukkonen","sequence":"first","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U. 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