{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:34:26Z","timestamp":1768343666832,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ankara University Scientific Research Projects Office, Ankara, Turkey","award":["08B3334005"],"award-info":[{"award-number":["08B3334005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue\/blood vessel\u2010type plasminogen activator (t\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) and plasminogen activator inhibitor\u20102 (<jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20102) in patients with periodontitis, with or without rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Fifteen patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and chronic periodontitis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010P), 15 systemically healthy patients with chronic periodontitis (H\u2010P) and 15 periodontally and systemically healthy volunteers (C) were included in the study. Plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing, gingival crevicular fluid t\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20102 levels, erythrocyte sedimentation rate, serum C\u2010reactive protein and disease activity score were evaluated at baseline and 3 mo after mechanical nonsurgical periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All periodontal clinical parameters were significantly higher in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010P and H\u2010P groups compared with the C group (<jats:italic>p<\/jats:italic> &lt; 0.001) and decreased significantly after treatment (<jats:italic>p<\/jats:italic> &lt; 0.001). Pretreatment t\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> levels were highest in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010P group and significantly decreased post\u2010treatment (<jats:italic>p<\/jats:italic> = 0.047). Pre\u2010 and post\u2010treatment <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20102 levels were significantly lower in controls compared with both periodontitis groups (<jats:italic>p<\/jats:italic> &lt; 0.05). Gingival crevicular fluid volume and the levels of t\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20102 were significantly correlated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with periodontitis and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, nonsurgical periodontal therapy reduced the pretreatment gingival crevicular fluid t\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> levels, which were significantly correlated with gingival crevicular fluid <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20102 levels. The significantly higher t\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20102 gingival crevicular fluid levels in periodontal patients, regardless of systemic status, suggest that the plasminogen activating system plays a role in the disease process of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12425","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T08:37:26Z","timestamp":1477471046000},"page":"574-581","source":"Crossref","is-referenced-by-count":34,"title":["Gingival crevicular fluid tissue\/blood vessel\u2010type plasminogen activator and plasminogen activator inhibitor\u20102 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy"],"prefix":"10.1111","volume":"52","author":[{"given":"\u015e.","family":"Kurgan","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"\u00d6nder","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Balc\u0131","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Istanbul Medipol University \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6.","family":"Fento\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Ankara Numune Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Balseven","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Pamukkale University Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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