{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:29:41Z","timestamp":1765546181638},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26670896"],"award-info":[{"award-number":["26670896"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Periodontal disease is a chronic inflammatory disease caused by bacterial infection that can lead to tooth loss. Gingival crevicular fluid can be collected easily and noninvasively. We previously discovered the presence of apolipoprotein B (apoB), the main constituent of low\u2010density lipoprotein, and oxidized low\u2010density lipoprotein (ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>) in the gingival crevicular fluid of healthy subjects. In this study, we investigated whether periodontal conditions affect the levels of apoB and ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> in gingival crevicular fluid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study population comprised 11 patients with chronic periodontitis. A pair of gingival crevicular fluid samples was collected from each patient at a healthy site and at a site with periodontitis (baseline samples). Thereafter, gingival crevicular fluid samples were collected from the same patients again at 4 and 8 wk after scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>). The levels of apoB, ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>, protein and cytokines in gingival crevicular fluid, in addition to gingival crevicular fluid volume, were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, the levels of apoB and ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> in gingival crevicular fluid were higher at the sites with periodontitis than at the healthy sites. The levels of apoB and oxLDL at periodontal sites decreased after <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. The level of ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> in gingival crevicular fluid correlated well with the probing pocket depth. The ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> : apoB ratio in gingival crevicular fluid was significantly higher than that in plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The levels of apoB and ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> in gingival crevicular fluid change according to the periodontal tissue conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12427","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T14:36:11Z","timestamp":1487946971000},"page":"594-602","source":"Crossref","is-referenced-by-count":9,"title":["Changes in apolipoprotein B and oxidized low\u2010density lipoprotein levels in gingival crevicular fluids as a result of periodontal tissue conditions"],"prefix":"10.1111","volume":"52","author":[{"given":"M.","family":"Ishizuka","sequence":"first","affiliation":[{"name":"Department of Periodontology Showa University School of Dentistry Tokyo Japan"},{"name":"Division of Biological Chemistry Department of Molecular Biology Showa University School of Pharmacy Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Biological Chemistry Department of Molecular Biology Showa University School of Pharmacy Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Periodontology Showa University School of Dentistry Tokyo Japan"},{"name":"Division of Biological Chemistry Department of Molecular Biology Showa University School of Pharmacy Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Showa University School of Dentistry Tokyo 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