{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:55:38Z","timestamp":1791557738791,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Recent studies have demonstrated the beneficial effects of omega\u20103 polyunsaturated fatty acids (PUFAs) on physiological processes and on a variety of chronic inflammatory diseases, including periodontal diseases. In this study, we evaluated the impact of omega\u20103 PUFAs in conjunction with scaling and root planing (SRP) on salivary markers in patients with chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Thirty systemically healthy subjects with chronic periodontitis were enrolled and randomly allocated into two groups. The control group (<jats:italic>n<\/jats:italic> = 15) was treated with SRP + placebo whereas the test group was treated with SRP and dietary supplementation of low\u2010dose omega\u20103 PUFAs (6.25 mg eicosapentaenoic acid and 19.19 mg docosahexaenoic acid). Clinical parameters were taken at baseline, 1, 3 and 6 mo following therapy. Saliva samples were obtained at the same time intervals and analyzed for tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and superoxide dismutase (SOD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed significant changes in clinical parameters in response to treatment compared to baseline with no significant difference between groups. Salivary TNF\u2010\u03b1 levels showed a statistically significant decrease in the test group at 6 mo compared to the control group. Salivary SOD levels increased significantly at 3 and 6 mo in the test group and at 6 mo in placebo groups compared to baseline with no statistically significant differences between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results demonstrated that dietary supplementation with low\u2010dose omega\u20103 PUFAs improves salivary TNF\u2010\u03b1 without any significant impact on clinical parameters in patients with chronic periodontitis, suggesting that the systemic benefits of dietary omega\u20103 PUFAs may not be translated to periodontal health. (ClinicalTrials.gov ID NCT02719587)<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12434","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T11:42:41Z","timestamp":1486554161000},"page":"695-703","source":"Crossref","is-referenced-by-count":49,"title":["Dietary supplementation with low\u2010dose omega\u20103 fatty acids reduces salivary tumor necrosis factor\u2010\u03b1 levels in patients with chronic periodontitis: a randomized controlled clinical study"],"prefix":"10.1111","volume":"52","author":[{"given":"I.","family":"Keskiner","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ondokuz Mayis University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Saygun","sequence":"additional","affiliation":[{"name":"Department of Periodontology Gulhane Military Medical Academy Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Periodontology Gulhane Military Medical Academy Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Serdar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine Acibadem University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Periodontology The Forsyth Institute Cambridge MA 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